CYLD: a deubiquitination enzyme with multiple roles in cancer.
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The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cellsDUBs, New Members in the Hypoxia Signaling clUbIdentification of new IκBα complexes by an iterative experimental and mathematical modeling approach.CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.CYLD deletion triggers nuclear factor-κB-signaling and increases cell death resistance in murine hepatocytes.CYLD Regulates Noscapine Activity in Acute Lymphoblastic Leukemia via a Microtubule-Dependent Mechanism.CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathwaysDownregulation of miR-362-5p inhibits proliferation, migration and invasion of human breast cancer MCF7 cellsInhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD.miR-186 suppressed CYLD expression and promoted cell proliferation in human melanomaFunctional interplay between cylindromatosis and histone deacetylase 6 in ciliary homeostasis revealed by phenotypic analysis of double knockout mice.Whole-exome sequencing identifies multiple loss-of-function mutations of NF-κB pathway regulators in nasopharyngeal carcinoma.Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling.CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation.Ubiquitination in disease pathogenesis and treatment.Deubiquitinases and the new therapeutic opportunities offered to cancer.Ubiquitin in regulation of spindle apparatus and its positioning: implications in development and disease.The role of deubiquitinating enzymes in spermatogenesis.Dishevelled proteins and CYLD reciprocally regulate each other in CML cell lines.Cylindromatosis--A Protective Molecule against Liver Diseases.Putative role of SUMOylation in controlling the activity of deubiquitinating enzymes in cancer.CYLD downregulates Livin and synergistically improves gemcitabine chemosensitivity and decreases migratory/invasive potential in bladder cancer: the effect is autophagy-associated.Post-translational control of NF-κB signaling by ubiquitination.Deubiquitinating activity of CYLD is impaired by SUMOylation in neuroblastoma cells.The role of deubiquitinases in breast cancer.CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so different.Tumor Suppressor Function of CYLD in Nonmelanoma Skin Cancer.Comparing nodal versus bony metastatic spread using tumour phylogenies.MiR-501-5p regulates CYLD expression and promotes cell proliferation in human hepatocellular carcinoma.Clinical significance of down-regulated cylindromatosis gene in chronic lymphocytic leukemia.Electroacupuncture Suppresses the NF-κB Signaling Pathway by Upregulating Cylindromatosis to Alleviate Inflammatory Injury in Cerebral Ischemia/Reperfusion Rats.Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease.MicroRNA‑1288 promotes cell proliferation of human glioblastoma cells by repressing ubiquitin carboxyl‑terminal hydrolase CYLD expression.CYLD controls c-MYC expression through the JNK-dependent signaling pathway in hepatocellular carcinoma.Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study.Ubiquitination and deubiquitination emerge as players in idiopathic pulmonary fibrosis pathogenesis and treatment.
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CYLD: a deubiquitination enzyme with multiple roles in cancer.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on February 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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CYLD: a deubiquitination enzyme with multiple roles in cancer.
@en
CYLD: a deubiquitination enzyme with multiple roles in cancer.
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CYLD: a deubiquitination enzyme with multiple roles in cancer.
@en
CYLD: a deubiquitination enzyme with multiple roles in cancer.
@nl
prefLabel
CYLD: a deubiquitination enzyme with multiple roles in cancer.
@en
CYLD: a deubiquitination enzyme with multiple roles in cancer.
@nl
P2860
P356
P1433
P1476
CYLD: a deubiquitination enzyme with multiple roles in cancer
@en
P2093
Ramin Massoumi
P2860
P304
P356
10.2217/FON.10.187
P407
P577
2011-02-01T00:00:00Z