EPHA3 as a novel therapeutic target in the hematological malignancies. - Wikidata - thesis-toulmin - TriplyDB

EPHA3 as a novel therapeutic target in the hematological malignancies.

EPHA3 as a novel therapeutic target in the hematological malignancies.

http://www.wikidata.org/entity/Q38025161

about

Eph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiation High expression of EphA3 (erythropoietin-producing hepatocellular A3) in gastric cancer is associated with metastasis and poor survival.Attenuation of eph receptor kinase activation in cancer cells by coexpressed ephrin ligands A high affinity recombinant antibody to the human EphA3 receptor with enhanced ADCC activity.Unliganded EphA3 dimerization promoted by the SAM domain.Therapeutic targeting of EPH receptors and their ligands.EphA3 biology and cancer.Inhibiting Eph kinase activity may not be "Eph"ective for cancer treatment.The role of Eph/ephrin molecules in stromal–hematopoietic interactions.Epha3 acts as proangiogenic factor in multiple myeloma.Monoclonal Antibody Therapies for Hematological Malignancies: Not Just Lineage-Specific Targets.EphA3 targeting reduces in vitro adhesion and invasion and in vivo growth and angiogenesis of multiple myeloma cells.Functional precision medicine identifies novel druggable targets and therapeutic options in head and neck cancer.

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EPHA3 as a novel therapeutic target in the hematological malignancies.

http://www.wikidata.org/entity/Q38025161

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EPHA3 as a novel therapeutic target in the hematological malignancies.

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EPHA3 as a novel therapeutic target in the hematological malignancies.

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EPHA3 as a novel therapeutic target in the hematological malignancies.

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Expert Review of Hematology

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EPHA3 as a novel therapeutic target in the hematological malignancies.

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Ciara Freeman

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Francis J Giles

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Niamh Keane

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Ronan Swords

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P2860

Eph receptors and ephrin ligands: important players in angiogenesis and tumor angiogenesis

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt

Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases

PTP1B regulates Eph receptor function and trafficking

Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines

Cell signaling by receptor tyrosine kinases

Prospective identification of tumorigenic breast cancer cells

EphA receptor signaling--complexity and emerging themes

Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10

P304

325-340

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scholarly article

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10.1586/EHM.12.19

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3

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5

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2012-06-01T00:00:00Z

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229063378

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22780212

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