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Association of Nuclear PIM1 Expression with Lymph Node Metastasis and Poor Prognosis in Patients with Lung Adenocarcinoma and Squamous Cell CarcinomaTargeting Pim kinases for cancer treatment: opportunities and challengesPim-1 kinase as cancer drug target: An updateThe role of PIM1/PIM2 kinases in tumors of the male reproductive systemCharacterization of HJ-PI01 as a novel Pim-2 inhibitor that induces apoptosis and autophagic cell death in triple-negative human breast cancerGenetic Modeling of PIM Proteins in Cancer: Proviral Tagging and Cooperation with Oncogenes, Tumor Suppressor Genes, and Carcinogens.In vitro evaluation of dihydropyridine-3-carbonitriles as potential cytotoxic agents through PIM-1 protein kinase inhibition.Mutational analysis of primary central nervous system lymphoma.Expression profiles of Fsh-regulated ovarian genes during oogenesis in coho salmon.A regulatory feedback loop between HIF-1α and PIM2 in HepG2 cellsOverexpression of pim-3 and protective role in lipopolysaccharide-stimulated hepatic stellate cellsPim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry.Chromosome 19q13 disruption alters expressions of CYP2A7, MIA and MIA-RAB4B lncRNA and contributes to FAP-like phenotype in APC mutation-negative familial colorectal cancer patients.Pim1 kinase promotes angiogenesis through phosphorylation of endothelial nitric oxide synthase at Ser-633.The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells.MicroRNA-124-3p regulates cell proliferation, invasion, apoptosis, and bioenergetics by targeting PIM1 in astrocytoma.Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition.Proviral insertion in murine lymphomas 2 (PIM2) oncogene phosphorylates pyruvate kinase M2 (PKM2) and promotes glycolysis in cancer cellsPhosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells.Alpinumisoflavone induces apoptosis in esophageal squamous cell carcinoma by modulating miR-370/PIM1 signaling.Acquired savolitinib resistance in non-small cell lung cancer arises via multiple mechanisms that converge on MET-independent mTOR and MYC activation.Harnessing allostery: a novel approach to drug discovery.Pre-clinical evidence of PIM kinase inhibitor activity in BCR-ABL1 unmutated and mutated Philadelphia chromosome-positive (Ph+) leukemias.The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression.PIM kinase (and Akt) biology and signaling in tumors.Synthesis of new pyridothienopyrimidinone derivatives as Pim-1 inhibitors.PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.Identification of cooperative genes for E2A-PBX1 to develop acute lymphoblastic leukemia.Elevated PIM2 gene expression is associated with poor survival of patients with acute myeloid leukemia.PIM1 induces cellular senescence through phosphorylation of UHRF1 at Ser311.Pim-2 Modulates Aerobic Glycolysis and Energy Production during the Development of Colorectal TumorsPIM and AKT kinase inhibitors show synergistic cytotoxicity in acute myeloid leukaemia that is associated with convergence on mTOR and MCL1 pathways.Expression and significance of Pim-3 kinase in adult T-cell leukemia.PIM1: a promising target in patients with triple-negative breast cancer.PIM-1 mRNA expression is a potential prognostic biomarker in acute myeloid leukemia.Expression of Pim-3 in colorectal cancer and its relationship with prognosis.Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer.Novel inhibition of PIM2 kinase has significant anti-tumor efficacy in multiple myeloma.Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus.The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
The PIM family of serine/threonine kinases in cancer.
@en
type
label
The PIM family of serine/threonine kinases in cancer.
@en
prefLabel
The PIM family of serine/threonine kinases in cancer.
@en
P2860
P356
P1476
The PIM family of serine/threonine kinases in cancer.
@en
P2093
Maja Narlik-Grassow
P2860
P304
P356
10.1002/MED.21284
P577
2013-04-10T00:00:00Z