Substrate specificity and kinetic framework of a DNAzyme with an expanded chemical repertoire: a putative RNaseA mimic that catalyzes RNA hydrolysis independent of a divalent metal cation.
about
DNA as a versatile chemical component for catalysis, encoding, and stereocontrolMerely two mutations switch a DNA-hydrolyzing deoxyribozyme from heterobimetallic (Zn2+/Mn2+) to monometallic (Zn2+-only) behavior.Synthesis and Enzymatic Incorporation of Modified Deoxyuridine Triphosphates.DNA and RNA induced enantioselectivity in chemical synthesis.A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M2+).A role for hydrophobicity in a Diels-Alder reaction catalyzed by pyridyl-modified RNA.Non-natural nucleotides as probes for the mechanism and fidelity of DNA polymerases.DNA Catalysis: The Chemical Repertoire of DNAzymes.Systematic characterization of 2'-deoxynucleoside- 5'-triphosphate analogs as substrates for DNA polymerases by polymerase chain reaction and kinetic studies on enzymatic production of modified DNARNase T1 mimicking artificial ribonuclease.Putative one-pot prebiotic polypeptides with ribonucleolytic activity.Hydroxyl-functionalized DNA: an efficient orthogonal protecting strategy and duplex stability.Systematic study of constraints imposed by modified nucleoside triphosphates with protein-like side chains for use in in vitro selection.Protein-inspired modified DNAzymes: dramatic effects of shortening side-chain length of 8-imidazolyl modified deoxyadenosines in selecting RNaseA mimicking DNAzymes.A densely modified M2+-independent DNAzyme that cleaves RNA efficiently with multiple catalytic turnover.
P2860
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P2860
Substrate specificity and kinetic framework of a DNAzyme with an expanded chemical repertoire: a putative RNaseA mimic that catalyzes RNA hydrolysis independent of a divalent metal cation.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
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2004年学术文章
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2004年学术文章
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2004年学术文章
@zh-my
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@zh-sg
2004年學術文章
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name
Substrate specificity and kine ...... nt of a divalent metal cation.
@en
type
label
Substrate specificity and kine ...... nt of a divalent metal cation.
@en
prefLabel
Substrate specificity and kine ...... nt of a divalent metal cation.
@en
P2093
P2860
P356
P1476
Substrate specificity and kine ...... nt of a divalent metal cation.
@en
P2093
David M Perrin
Jason M Thomas
Leonard Lermer
Richard Ting
P2860
P304
P356
10.1093/NAR/GKH1007
P407
P577
2004-12-29T00:00:00Z