Unleashing the therapeutic potential of human kallikrein-related serine proteases. - Wikidata - thesis-toulmin - TriplyDB

Unleashing the therapeutic potential of human kallikrein-related serine proteases.

Unleashing the therapeutic potential of human kallikrein-related serine proteases.

http://www.wikidata.org/entity/Q38362486

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Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes Effects of Glycosylation on the Enzymatic Activity and Mechanisms of Proteases Tissue Kallikrein Inhibitors Based on the Sunflower Trypsin Inhibitor Scaffold - A Potential Therapeutic Intervention for Skin Diseases Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics.Crucial role of estrogen for the mammalian female in regulating semen coagulation and liquefaction in vivo.Protease-Inhibitor Interaction Predictions: Lessons on the Complexity of Protein-Protein Interactions Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients A Multiplex Protein Panel Applied to Cerebrospinal Fluid Reveals Three New Biomarker Candidates in ALS but None in Neuropathic Pain Patients.Kallistatin ameliorates influenza virus pathogenesis by inhibition of kallikrein-related peptidase 1-mediated cleavage of viral hemagglutinin Virtual Screening of Small Drug-Like Compounds Stimulating the Enzymatic Activity of Kallikrein-Related Peptidase 3 (KLK3).Kallikreins - The melting pot of activity and function LRRC31 is induced by IL-13 and regulates kallikrein expression and barrier function in the esophageal epithelium.A new enzyme-linked immunosorbent assay (ELISA) for human free and bound kallikrein 9.Transcriptome reveals the overexpression of a kallikrein gene cluster (KLK1/3/7/8/12) in the Tibetans with high altitude-associated polycythemia.Detection of Enzyme Activity and Inhibition during Studies in Solution, In Vitro and In Vivo with CatalyCEST MRI.Kallikrein-related peptidase 4 induces cancer-associated fibroblast features in prostate-derived stromal cells Kallikrein-related peptidases (KLKs) and the hallmarks of cancer.Kallikrein-related peptidases (KLKs) as emerging therapeutic targets: focus on prostate cancer and skin pathologies.Putative functions of tissue kallikrein-related peptidases in vaginal fluid.Emerging challenges in the design of selective substrates, inhibitors and activity-based probes for indistinguishable proteases.Expression of Kallikrein-Related Peptidase 6 in Primary Mucosal Malignant Melanoma of the Head and Neck.Staphylococcus aureus Induces Increased Serine Protease Activity in Keratinocytes.Inhibitors of kallikrein-related peptidases: An overview.Epithelial-to-Mesenchymal Transition in the Pathogenesis and Therapy of Head and Neck Cancer Quantification of Human Kallikrein-Related Peptidases in Biological Fluids by Multiplatform Targeted Mass Spectrometry Assays.The Role of Fibroblast Growth Factor Binding Protein 1 in Skin Carcinogenesis and Inflammation.Transition to an Aquatic Habitat Permitted the Repeated Loss of the Pleiotropic KLK8 Gene in Mammals.Clinical relevance of kallikrein-related peptidase 6 (KLK6) and 8 (KLK8) mRNA expression in advanced serous ovarian cancer.KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes.Molecular cloning of novel transcripts of human kallikrein-related peptidases 5, 6, 7, 8 and 9 (KLK5 - KLK9), using Next-generation sequencing.Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.Serine protease inhibitors to treat inflammation: a patent review (2011-2016).Collection of Post-mating Semen from the Female Reproductive Tract and Measurement of Semen Liquefaction in Mice.Mass spectrometry based proteomics analyses in kallikrein-related peptidase research: implications for cancer research and therapy.Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo.Dysregulated Metabolism of the Amyloid-β Protein and Therapeutic Approaches in Alzheimer Disease.Downregulated KLK13 expression in bladder cancer highlights tumor aggressiveness and unfavorable patients' prognosis.Identification of prefrontal cortex protein alterations in Alzheimer's disease.Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types.A distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate.

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P2860

Unleashing the therapeutic potential of human kallikrein-related serine proteases.

http://www.wikidata.org/entity/Q38362486

description

2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年學術文章

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2015年學術文章

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2015年學術文章

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name

Unleashing the therapeutic potential of human kallikrein-related serine proteases.

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type

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Unleashing the therapeutic potential of human kallikrein-related serine proteases.

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prefLabel

Unleashing the therapeutic potential of human kallikrein-related serine proteases.

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Nature Reviews Drug Discovery

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Unleashing the therapeutic potential of human kallikrein-related serine proteases.

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Azza Eissa

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Gennadiy Poda

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Ioannis Prassas

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P2860

Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation

LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum

Role of kallikrein enzymes in the central nervous system

Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins

Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta

Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors

Major role of human KLK14 in seminal clot liquefaction

LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome

A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation

A proteolytic cascade of kallikreins in the stratum corneum

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183-202

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10.1038/NRD4534

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3

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14

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Eleftherios P. Diamandis

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2015-02-20T00:00:00Z

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25698643

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