A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation.
about
Biphasic regulation of lysosomal exocytosis by oxidative stressTwo-Pore Channels and Parkinson's Disease: Where's the Link?HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPases.Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function.TRPML1 as lysosomal fusion guard.The lysosome as a command-and-control center for cellular metabolism.PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis.A painful TR(i)P to lysosomes.Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel.The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes.The renal Fanconi syndrome in cystinosis: pathogenic insights and therapeutic perspectives.Salmonella effector SopD2 interferes with Rab34 function.Mechanisms and functions of lysosome positioning.Deregulated ALG-2/HEBP2 axis alters microtubule dynamics and mitotic spindle behavior to stimulate cancer development.Drinking problems: mechanisms of macropinosome formation and maturation.On the structure and mechanism of two-pore channels.Exacerbating and reversing lysosomal storage diseases: from yeast to humans.REP1 Modulates Autophagy and Macropinocytosis to Enhance Cancer Cell Survival.Autophagosomes take the Klp98-A train.Folliculin - A tumor suppressor at the intersection of metabolic signaling and membrane traffic.BORC coordinates encounter and fusion of lysosomes with autophagosomes.TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.ATP13A2/PARK9 regulates endo-/lysosomal cargo sorting and proteostasis through a novel PI(3, 5)P2-mediated scaffolding function.Human TRPML1 channel structures in open and closed conformations.Probing and manipulating intracellular membrane traffic by microinjection of artificial vesicles.Lysosomal Calcium in Neurodegeneration.The lysosomal Ca2+ release channel TRPML1 regulates lysosome size by activating calmodulin.Endolysosomal Cation Channels and Cancer-A Link with Great Potential.Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states.Lysosome signaling controls the migration of dendritic cells.PtdIns3P controls mTORC1 signaling through lysosomal positioning.LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning.Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation.Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney.mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate.Phosphoinositide conversion in endocytosis and the endolysosomal system.A negative feedback regulation of MTORC1 activity by the lysosomal Ca2+ channel MCOLN1 (mucolipin 1) using a CALM (calmodulin)-dependent mechanism.Mechanisms and function of autophagy in intestinal disease.Quantification of Endosome and Lysosome Motilities in Cultured Neurons Using Fluorescent Probes.Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca2+ Efflux Channel in the Tubulovesicle.
P2860
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P2860
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
A molecular mechanism to regul ...... me positioning and tubulation.
@en
type
label
A molecular mechanism to regul ...... me positioning and tubulation.
@en
prefLabel
A molecular mechanism to regul ...... me positioning and tubulation.
@en
P2093
P2860
P356
P1433
P1476
A molecular mechanism to regul ...... ome positioning and tubulation
@en
P2093
Ahmad Hider
Haoxing Xu
Nicholas Rydzewski
Xiaoli Zhang
Xiping Cheng
P2860
P2888
P304
P356
10.1038/NCB3324
P577
2016-03-07T00:00:00Z
P5875
P6179
1013915833