Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy.
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Molecular and evolutionary insights into the structural organization of cation chloride cotransportersMutations in SLC12A5 in epilepsy of infancy with migrating focal seizures.Cation-chloride cotransporters in neuronal development, plasticity and diseaseKCC2 activity is critical in limiting the onset and severity of status epilepticus.Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures.Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophreniaDetrimental effect of post Status Epilepticus treatment with ROCK inhibitor Y-27632 in a pilocarpine model of temporal lobe epilepsy.A noninvasive optical approach for assessing chloride extrusion activity of the K-Cl cotransporter KCC2 in neuronal cells.Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target.Impaired neuronal KCC2 function by biallelic SLC12A5 mutations in migrating focal seizures and severe developmental delayA patient with multisystem dysfunction carries a truncation mutation in human SLC12A2, the gene encoding the Na-K-2Cl cotransporter, NKCC1.Compromising KCC2 transporter activity enhances the development of continuous seizure activity.Locus Heterogeneity in Epilepsy of Infancy with Migrating Focal Seizures.The K(+)-Cl(-) Cotransporter KCC2 and Chloride Homeostasis: Potential Therapeutic Target in Acute Central Nervous System Injury.Molecular cloning and biochemical characterization of two cation chloride cotransporter subfamily members of Hydra vulgaris.GABAergic Transmission during Brain Development: Multiple Effects at Multiple Stages.Developmental Expression Patterns of KCC2 and Functionally Associated Molecules in the Human Brain.WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.A Novel View on the Role of Intracellular Tails in Surface Delivery of the Potassium-Chloride Cotransporter KCC2The KCl-cotransporter KCC2 linked to epilepsy.Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibitionK+-Cl- co-transporter 2 (KCC2) - a membrane trafficking perspective.N-Ethylmaleimide increases KCC2 cotransporter activity by modulating transporter phosphorylation.Retracing your footsteps: developmental insights to spinal network plasticity following injury.Dysregulation of Cortical Neuron DNA Methylation Profile in Autism Spectrum Disorder.Restoring GABAergic inhibition rescues memory deficits in a Huntington's disease mouse model.A de novo missense mutation in SLC12A5 found in a compound heterozygote patient with epilepsy of infancy with migrating focal seizures.A kainate receptor subunit promotes the recycling of the neuron-specific K+-Cl- co-transporter KCC2 in hippocampal neurons.Pro-Brain-Derived Neurotrophic Factor (proBDNF)-Mediated p75NTR Activation Promotes Depolarizing Actions of GABA and Increases Susceptibility to Epileptic Seizures.Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome.The KCC2 Cotransporter and Human Epilepsy: Getting Excited About Inhibition.Mechanism of BDNF Modulation in GABAergic Synaptic Transmission in Healthy and Disease BrainsM-Calpain Activation Facilitates Seizure Induced KCC2 Down RegulationDifferential regulation of chloride homeostasis and GABAergic transmission in the thalamusThe Effects of Ginsenoside Compound K Against Epilepsy by Enhancing the γ-Aminobutyric Acid Signaling Pathway
P2860
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P2860
Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
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2014年學術文章
@zh-hant
name
Genetically encoded impairment ...... iopathic generalized epilepsy.
@en
type
label
Genetically encoded impairment ...... iopathic generalized epilepsy.
@en
prefLabel
Genetically encoded impairment ...... iopathic generalized epilepsy.
@en
P2093
P2860
P50
P356
P1433
P1476
Genetically encoded impairment ...... iopathic generalized epilepsy.
@en
P2093
Annie Levert
Arjun Khanna
Brian Walcott
Cynthia Bourassa
Hamid Nikbakht
Jacek Majewski
Kristopher T Kahle
Liliya Silayeva
Patrick Cossette
Perrine Friedel
P2860
P304
P356
10.15252/EMBR.201438840
P50
P577
2014-06-13T00:00:00Z