FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease.
about
Fingolimod for multiple sclerosis and emerging indications: appropriate patient selection, safety precautions, and special considerationsFingolimod for the treatment of neurological diseases-state of play and future perspectivesPreclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-MitoxyProgressive multiple sclerosis: from pathogenic mechanisms to treatment.Novel FTY720-Based Compounds Stimulate Neurotrophin Expression and Phosphatase Activity in Dopaminergic Cells.Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease.Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdownFTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice: CONTRIBUTIONS OF PRO-BRAIN-DERIVED NEUROTROPHIC FACTOR (PRO-BDNF) AND MATURE BDNF.The Effect of Fingolimod on Conversion of Acute Gadolinium-Enhancing Lesions to Chronic T1 Hypointensities in Multiple Sclerosis.Progressive MS: from pathophysiology to drug discovery.Pridopidine, a dopamine stabilizer, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model.Cognitive dysfunction in Huntington's disease: mechanisms and therapeutic strategies beyond BDNF.Crosstalk between sphingolipids and vitamin D3: potential role in the nervous system.Revealing disease-associated pathways by network integration of untargeted metabolomics.Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis.Impaired Levels of Gangliosides in the Corpus Callosum of Huntington Disease Animal ModelsActivation of S1P₁ receptor regulates PI3K/Akt/FoxO3a pathway in response to oxidative stress in PC12 cells.Motor phenotype is not associated with vascular dysfunction in symptomatic Huntington's disease transgenic R6/2 (160 CAG) miceLoss of Sphingosine Kinase Alters Life History Traits and Locomotor Function in Caenorhabditis elegans.The sphingosine 1-phosphate receptor agonist FTY720 is neuroprotective after cuprizone-induced CNS demyelination.Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation.Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease.FTY720 Attenuates 6-OHDA-Associated Dopaminergic Degeneration in Cellular and Mouse Parkinsonian Models.Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.Glyco-sphingo biology: a novel perspective for potential new treatments in Huntington's disease.De novo Synthesis of Sphingolipids Is Defective in Experimental Models of Huntington's Disease.Sphingolipid Metabolism: A New Therapeutic Opportunity for Brain Degenerative Disorders.
P2860
Q26765300-81A202D6-E9BE-48CD-9BC5-7669DC627A19Q27026175-B74A2617-9D71-4B10-9A2C-7AD099387A8AQ28553993-9DFE814D-E4DE-4AED-B5C5-1C0FF0DCF335Q31139925-8EEDADF5-54DA-4E1E-8DDC-37AA2FB6E2F0Q33889032-46BC9067-7220-4FC6-B6B9-2C86E8E2B897Q33902931-155891A8-C2B6-47D1-B289-375F2F39ED1DQ35168414-867AF012-82BF-43EA-9FD9-0E5D5BAF8F22Q37277536-EAEB35F0-0B28-4E8B-B385-09776D50C619Q37325966-DB7454CC-F044-4720-AC63-46610F4071F2Q38585418-B4560AB1-6237-4D5D-A872-58B450633BDBQ38861728-FD9BE2D9-3958-4C6D-8E75-4937D1E9FAC4Q38928777-3EDA676C-090C-455B-9392-D88153D11541Q39106107-82CC0054-1D63-469A-9176-A4354AE5123AQ39538215-C7B85280-C6DB-4190-B003-595754CF2F8CQ39561307-0F651910-E71B-4D39-AD13-6334D9E92CE3Q41340916-B7E59D70-4E2D-498E-9187-8DE445137BE3Q41656417-1080BB7D-DCB3-494F-972C-21DA7ACE9D2DQ41842714-18DA9228-9C27-4A66-957A-96D32830965CQ41952712-02F556CB-D357-46BA-8194-CC8384128574Q41958515-9A4264CB-AACB-4065-AF01-5B56AD685C2EQ45288581-A55EC112-7FBA-42AE-801F-6D581240CE18Q45295362-728DCBD0-FEAE-43F5-BA77-C8312B17D2F9Q45299524-FEAF5833-0C5A-4C21-8F24-5F81764D7800Q45305618-01279F3B-0863-47D8-A7CF-1A5061305A06Q47098894-0A31BEC3-1EA2-4D27-9546-A59154F07728Q47273613-39C38B79-2B7C-4C4C-BB4A-3986E6E14E4BQ55122433-B206B000-24E0-4E54-90B6-C1AE8D05D52A
P2860
FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
FTY720 (fingolimod) is a neuro ...... models of Huntington disease.
@en
FTY720
@nl
type
label
FTY720 (fingolimod) is a neuro ...... models of Huntington disease.
@en
FTY720
@nl
prefLabel
FTY720 (fingolimod) is a neuro ...... models of Huntington disease.
@en
FTY720
@nl
P2860
P50
P356
P1476
FTY720 (fingolimod) is a neuro ...... e models of Huntington disease
@en
P2093
Mariagrazia Favellato
Roberta Castrataro
P2860
P304
P356
10.1093/HMG/DDT615
P577
2013-12-02T00:00:00Z