A2E induces IL-1ß production in retinal pigment epithelial cells via the NLRP3 inflammasome.
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Update on Clinical Trials in Dry Age-related Macular DegenerationInflammation and its role in age-related macular degenerationParainflammation, chronic inflammation, and age-related macular degenerationNLRP3 Inflammasome and Pathobiology in AMDNLRP3 inflammasome: activation and regulation in age-related macular degenerationLuteoloside suppresses proliferation and metastasis of hepatocellular carcinoma cells by inhibition of NLRP3 inflammasomeNorbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In VivoOxidized Lipoprotein Uptake Through the CD36 Receptor Activates the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells.Immune responses in age-related macular degeneration and a possible long-term therapeutic strategy for preventionAge-related macular degeneration: insights into inflammatory genes.Gene delivery of a viral anti-inflammatory protein to combat ocular inflammationMorphological and physiological retinal degeneration induced by intravenous delivery of vitamin A dimers in rabbits.Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interleukin-17 receptor acting as a cytokine blocker: implications for age-related macular degeneration.Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1β and IL-18.Interleukin-1β Level Is Increased in Vitreous of Patients with Neovascular Age-Related Macular Degeneration (nAMD) and Polypoidal Choroidal Vasculopathy (PCV).A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in miceIron Toxicity in the Retina Requires Alu RNA and the NLRP3 InflammasomeImpairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis.A local complement response by RPE causes early-stage macular degeneration.Responses of Multipotent Retinal Stem Cells to IL-1β, IL-18, or IL-17P2Y1 Receptor Signaling Contributes to High Salt-Induced Priming of the NLRP3 Inflammasome in Retinal Pigment Epithelial Cells.Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degenerationRetinoic Acid Receptor Beta in Pathophysiology of Age-Related Macular Degeneration.NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence.Cholesterol crystals induce inflammatory cytokines expression in a human retinal pigment epithelium cell line by activating the NF-κB pathway.Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium.Role of macrophages in age-related oxidative stress and lipofuscin accumulation in mice.Studying melanin and lipofuscin in RPE cell culture models.Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: evidence for a role in retinal degenerations.Role of inflammasome activation in the pathophysiology of vascular diseases of the neurovascular unit.Complement Component C5a Primes Retinal Pigment Epithelial Cells for Inflammasome Activation by Lipofuscin-mediated Photooxidative DamageMitochondrial DNA has a pro-inflammatory role in AMD.THE PATHOPHYSIOLOGY OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION AND THE COMPLEMENT PATHWAY AS A THERAPEUTIC TARGET.The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD.Reduced photoreceptor death and improved retinal function during retinal degeneration in mice lacking innate immunity adaptor protein MyD88.Conditional, Genetically Encoded, Small Molecule-Regulated Inhibition of NFκB Signaling in RPE Cells.Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage.cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration.Evidence for the activation of pyroptotic and apoptotic pathways in RPE cells associated with NLRP3 inflammasome in the rodent eye.
P2860
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P2860
A2E induces IL-1ß production in retinal pigment epithelial cells via the NLRP3 inflammasome.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
A2E induces IL-1ß production i ...... ls via the NLRP3 inflammasome.
@en
A2E induces IL-1ß production i ...... ls via the NLRP3 inflammasome.
@nl
type
label
A2E induces IL-1ß production i ...... ls via the NLRP3 inflammasome.
@en
A2E induces IL-1ß production i ...... ls via the NLRP3 inflammasome.
@nl
prefLabel
A2E induces IL-1ß production i ...... ls via the NLRP3 inflammasome.
@en
A2E induces IL-1ß production i ...... ls via the NLRP3 inflammasome.
@nl
P2093
P2860
P1433
P1476
A2E induces IL-1ß production i ...... ls via the NLRP3 inflammasome.
@en
P2093
Arthur Finkelstein
David T Shima
Owen A Anderson
P2860
P304
P356
10.1371/JOURNAL.PONE.0067263
P407
P577
2013-06-28T00:00:00Z