about
Inhibition of 2'-5' oligoadenylate synthetase by divalent metal ionsThe oligoadenylate synthetase family: an ancient protein family with multiple antiviral activitiesConformational diversity in prion protein variants influences intermolecular beta-sheet formationThe p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domainModular structure of PACT: distinct domains for binding and activating PKREfficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potentialCrystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetaseInterferon- Is Functionally an Interferon but Structurally Related to the Interleukin-10 FamilySelection of a Novel and Highly Specific Tumor Necrosis Factor (TNF ) Antagonist: INSIGHT FROM THE CRYSTAL STRUCTURE OF THE ANTAGONIST-TNF COMPLEXCrystal Structure of Interleukin-21 Receptor (IL-21R) Bound to IL-21 Reveals That Sugar Chain Interacting with WSXWS Motif Is Integral Part of IL-21RThe crystal structure of zebrafish IL-22 reveals an evolutionary, conserved structure highly similar to that of human IL-22Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6Natural mutations in a 2'-5' oligoadenylate synthetase transgene revealed residues essential for enzyme activityAn important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activityPandemic H1N1 2009 influenza A virus induces weak cytokine responses in human macrophages and dendritic cells and is highly sensitive to the antiviral actions of interferons.Selective degradation of 2'-adenylated diadenosine tri- and tetraphosphates, Ap(3)A and Ap(4)A, by two specific human dinucleoside polyphosphate hydrolases.Gene structure and function of the 2'-5'-oligoadenylate synthetase family.Human interferon-lambda3 is a potent member of the type III interferon family.Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signalingFunctional IRF3 deficiency in a patient with herpes simplex encephalitis.Antiviral Activities of Different Interferon Types and Subtypes against Hepatitis E Virus Replication.Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronavirusesThe structure of human interferon lambda and what it has taught us.OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids.The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation.Guarding the frontiers: the biology of type III interferons.Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.Cellular Mechanism for Impaired Hepatitis C Virus Clearance by Interferon Associated with IFNL3 Gene Polymorphisms Relates to Intrahepatic Interferon-λ Expression.Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes.Lambda Interferons: New Cytokines with Old Functions.Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity.Rational design of interleukin-21 antagonist through selective elimination of the gammaC binding epitope.Differential regulation of the OASL and OAS1 genes in response to viral infections.cGAS is activated by DNA in a length-dependent manner.Type III interferon (IFN) induces a type I IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-STAT pathway and the mitogen-activated protein kinases.IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis.A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.Identification of essential regulatory elements responsible for the explicit expression of IL-28Rα and their effect on critical SNPs using in-Silico methods.IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment.
P50
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P50
description
hulumtues
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onderzoeker
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researcher
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հետազոտող
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Rune Hartmann
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Rune Hartmann
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Rune Hartmann
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Rune Hartmann
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Rune Hartmann
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Rune Hartmann
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Rune Hartmann
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Rune Hartmann
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Rune Hartmann
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Rune Hartmann
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Rune Hartmann
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Rune Hartmann
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Rune Hartmann
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Rune Hartmann
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Rune Hartmann
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P106
P1153
56208223400
P21
P31
P496
0000-0003-1159-066X