Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential.
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High glucose-mediated oxidative stress impairs cell migration.REDD1 protects osteoblast cells from gamma radiation-induced premature senescenceSuppression of replicative senescence by rapamycin in rodent embryonic cellsWhy men age faster but reproduce longer than women: mTOR and evolutionary perspectivesDNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescenceHyper-mitogenic drive coexists with mitotic incompetence in senescent cells.Optimization of human corneal endothelial cell culture: density dependency of successful cultures in vitromTOR Signaling from Cellular Senescence to Organismal AgingParadoxical suppression of cellular senescence by p53Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes.Metformin and sex: Why suppression of aging may be harmful to young male mice.Statin prevents chondrocyte aging and degeneration of articular cartilage in osteoarthritis (OA).Cell size and growth rate are major determinants of replicative lifespan.Inhibition of activated pericentromeric SINE/Alu repeat transcription in senescent human adult stem cells reinstates self-renewalRas/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health.Molecular damage in cancer: an argument for mTOR-driven agingNCI's provocative questions on cancer: some answers to ignite discussion.Automated image analysis of nuclear shape: what can we learn from a prematurely aged cell?Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging.Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone productionGeroconversion: irreversible step to cellular senescenceTumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restrictionTranscriptional profiling of interleukin-2-primed human adipose derived mesenchymal stem cells revealed dramatic changes in stem cells response imposed by replicative senescence.PC-1/PrLZ confers resistance to rapamycin in prostate cancer cells through increased 4E-BP1 stabilityDual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).Hypoxia and gerosuppression: the mTOR saga continuesAnswering the ultimate question "what is the proximal cause of aging?"Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging.Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questions.Nuclear DNA methylation and chromatin condensation phenotypes are distinct between normally proliferating/aging, rapidly growing/immortal, and senescent cells.M(o)TOR of aging: MTOR as a universal molecular hypothalamusChronic rapamycin treatment or lack of S6K1 does not reduce ribosome activity in vivo.Aging is not programmed: genetic pseudo-program is a shadow of developmental growth.Gerosuppression by pan-mTOR inhibitors.Cell cycle arrest is not senescence.Quasi-programmed aging of budding yeast: a trade-off between programmed processes of cell proliferation, differentiation, stress response, survival and death defines yeast lifespan.Progeria, rapamycin and normal aging: recent breakthrough.Signaling pathways as therapeutic targets in biliary tract cancer.On-demand weighing of single dry biological particles over a 5-order-of-magnitude dynamic range.
P2860
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P2860
Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh
2009年學術文章
@zh-hant
name
Quantifying pharmacologic supp ...... on of proliferative potential.
@en
Quantifying pharmacologic supp ...... on of proliferative potential.
@nl
type
label
Quantifying pharmacologic supp ...... on of proliferative potential.
@en
Quantifying pharmacologic supp ...... on of proliferative potential.
@nl
prefLabel
Quantifying pharmacologic supp ...... on of proliferative potential.
@en
Quantifying pharmacologic supp ...... on of proliferative potential.
@nl
P2860
P356
P1433
P1476
Quantifying pharmacologic supp ...... on of proliferative potential.
@en
P2093
Zoya N Demidenko
P2860
P304
P356
10.18632/AGING.100115
P577
2009-12-31T00:00:00Z