Oncogene-induced senescence does not require the p16(INK4a) or p14ARF melanoma tumor suppressors.
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In vitro evidence for senescent multinucleated melanocytes as a source for tumor-initiating cells.Generation of a genome scale lentiviral vector library for EF1α promoter-driven expression of human ORFs and identification of human genes affecting viral titerThe relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence.Initiation of premature senescence by Bcl-2 in hypoxic condition.High-level expression of wild-type p53 in melanoma cells is frequently associated with inactivity in p53 reporter gene assaysMechanisms of chromosomal instability in melanoma.iPSCs as a major opportunity to understand and cure age-related diseases.Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis.The essence of senescence.The p16(INK4A) tumor suppressor regulates cellular oxidative stressEZH2-dependent suppression of a cellular senescence phenotype in melanoma cells by inhibition of p21/CDKN1A expression.mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence.Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effeA prognostic signature of defective p53-dependent G1 checkpoint function in melanoma cell linesCDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma.Pathways of oncogene-induced senescence in human melanocytic cellsOncogene-induced senescence and melanoma: where do we stand?Melanocytic nevi and melanoma: unraveling a complex relationship.Secondary c-Kit mutations confer acquired resistance to RTK inhibitors in c-Kit mutant melanoma cells.p15 Expression Differentiates Nevus from Melanoma.Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor.Nevus senescence.Senescence and Telomere Homeostasis Might Be Involved in Placenta Percreta-Preliminary Investigation.A short acidic motif in ARF guards against mitochondrial dysfunction and melanoma susceptibility.p16(INK) (4a) deficiency promotes DNA hyper-replication and genetic instability in melanocytes.Oncogenic PI3K/AKT promotes the step-wise evolution of combination BRAF/MEK inhibitor resistance in melanoma
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P2860
Oncogene-induced senescence does not require the p16(INK4a) or p14ARF melanoma tumor suppressors.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
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2009年学术文章
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2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
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2009年學術文章
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2009年學術文章
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name
Oncogene-induced senescence does not require the p16
@nl
Oncogene-induced senescence do ...... RF melanoma tumor suppressors.
@en
type
label
Oncogene-induced senescence does not require the p16
@nl
Oncogene-induced senescence do ...... RF melanoma tumor suppressors.
@en
prefLabel
Oncogene-induced senescence does not require the p16
@nl
Oncogene-induced senescence do ...... RF melanoma tumor suppressors.
@en
P2093
P50
P356
P1476
Oncogene-induced senescence do ...... ARF melanoma tumor suppressors
@en
P2093
Lyndee L Scurr
Monika Frausto
Sebastian Haferkamp
P2888
P304
P356
10.1038/JID.2009.5
P407
P577
2009-02-12T00:00:00Z