about
Generalized immune activation as a direct result of activated CD4+ T cell killingSHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosisThe deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cellsOsteoclast differentiation factor RANKL controls development of progestin-driven mammary cancerSustained oscillations of NF-kappaB produce distinct genome scanning and gene expression profilesConditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistanceIKK mediates ischemia-induced neuronal deathHepatocyte IKK2 protects Mdr2-/- mice from chronic liver failureIKK2 inhibition attenuates laser-induced choroidal neovascularizationM17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in miceTumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in miceNEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte ApoptosisImmune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune reIkappaB kinase signaling is essential for maintenance of mature B cellsThe tumour suppressor CYLD regulates the p53 DNA damage responseImproved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous systemMK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death.Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alphaEndothelial and macrophage-specific deficiency of P38α MAPK does not affect the pathogenesis of atherosclerosis in ApoE-/- mice.Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis.Epidermal p65/NF-κB signalling is essential for skin carcinogenesisCutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivoListeria monocytogenes infection in macrophages induces vacuolar-dependent host miRNA response.Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection.Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunits.RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosisHematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis.Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout.Synchronized renal tubular cell death involves ferroptosis.Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis.Cigarette smoke induced airway inflammation is independent of NF-κB signallingTargeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regenerationHematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway.NF-κB in the regulation of epithelial homeostasis and inflammation.Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis.Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent.Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Manolis Pasparakis
@ast
Manolis Pasparakis
@en
Manolis Pasparakis
@es
Manolis Pasparakis
@nl
Manolis Pasparakis
@sl
type
label
Manolis Pasparakis
@ast
Manolis Pasparakis
@en
Manolis Pasparakis
@es
Manolis Pasparakis
@nl
Manolis Pasparakis
@sl
prefLabel
Manolis Pasparakis
@ast
Manolis Pasparakis
@en
Manolis Pasparakis
@es
Manolis Pasparakis
@nl
Manolis Pasparakis
@sl
P106
P21
P31
P496
0000-0002-9870-0966