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Correlating in vitro data to in vivo findings for risk assessment.Evaluation of CYP3A4 inhibition and hepatotoxicity using DMSO-treated human hepatoma HuH-7 cells.Sex hormone modulation of both induction and inhibition of CYP1A by genistein in HepG2/C3A cells.Use of the Combination Index to determine interactions between plant-derived phenolic acids on hepatotoxicity endpoints in human and rat hepatoma cells.Cellular glutathione in fatty liver in vitro models.Multiendpoint mechanistic profiling of hepatotoxicants in HepG2/C3A human hepatoma cells and novel statistical approaches for development of a prediction model for acute hepatotoxicity.Rat liver clone-9 cells in culture as a model for screening hepatotoxic potential of food-related products: hepatotoxicity of deoxynivalenol.Validation of an in vitro model for assessment of androstenedione hepatotoxicity using the rat liver cell line clone-9.CYP3A4 inhibition by Psoralea corylifolia and its major components in human recombinant enzyme, differentiated human hepatoma HuH-7 and HepaRG cells.Effects of dietary phenolics and botanical extracts on hepatotoxicity-related endpoints in human and rat hepatoma cells and statistical models for prediction of hepatotoxicity.Statement of the Public Affairs Committee of the Teratology Society on the fetal alcohol syndrome.Flaxseed increased alpha-linolenic and eicosapentaenoic acid and decreased arachidonic acid in serum and tissues of rat dams and offspring.Impact of high flaxseed diet on mitogen-induced proliferation, IL-2 production, cell subsets and fatty acid composition of spleen cells from pregnant and F1 generation Sprague-Dawley rats.Hepatotoxicity of androstenedione in pregnant rats.Effects of oral androstenedione on steroid metabolism in liver of pregnant and non-pregnant female rats.Distribution of androstenedione and its effects on total free fatty acids in pregnant rats.Effects of oral androstenedione on phospholipid fatty acids, ATP, caspase-3, prostaglandin E(2) and C-reactive protein in serum and livers of pregnant and non-pregnant female rats.Effects of flaxseed and defatted flaxseed meal on reproduction and development in rats.Sulfogalactosyl diacylglycerol: occurrence and biosynthesis of a novel lipid in rat brain.Developmental changes of myelin-related lipids in brain of miniature swine.Effects of ischemia-hypoxia induced by interruption of uterine blood flow on fetal rat liver and brain enzyme activities and offspring behavior.Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture.State of the art in developmental toxicity screening methods and a way forward: a meeting report addressing embryonic stem cells, whole embryo culture, and zebrafish.Developmental effects of serum from flaxseed-fed rats on cultured rat embryos.Developmental effects of combined exposure to ethanol and vitamin A.Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesisAssessment of the embryotoxic potential of the total hydrolysis product of fumonisin B1 using cultured organogenesis-staged rat embryosEffect of ethanol and vitamin A excess on vitamin A status in the liver, plasma and foetuses of pregnant ratsRat embryo culture to detect nutritional deficiency in women with poor reproductive historiesEffects of puromycin on rat embryos in vitro
P50
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P50
description
hulumtues
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researcher
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հետազոտող
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Thomas J. Flynn
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Thomas J. Flynn
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Thomas J. Flynn
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Thomas J. Flynn
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Thomas J. Flynn
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Thomas J. Flynn
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Thomas J. Flynn
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Thomas J. Flynn
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Thomas J. Flynn
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Thomas J. Flynn
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Thomas J. Flynn
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Thomas J. Flynn
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P106
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P21
P31
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0000-0002-7248-0643