about
The role of toxicological science in meeting the challenges and opportunities of hydraulic fracturingThe SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiativeMetabolism of benzo[a]pyrene in human bronchoalveolar H358 cells using liquid chromatography-mass spectrometryInhibition of human steroid 5beta-reductase (AKR1D1) by finasteride and structure of the enzyme-inhibitor complexIdentification of the molecular switch that regulates access of 5alpha-DHT to the androgen receptorAndrogen biosynthesis in castration-resistant prostate cancerIntense androgen-deprivation therapy with abiraterone acetate plus leuprolide acetate in patients with localized high-risk prostate cancer: results of a randomized phase II neoadjuvant study.Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholateCrystal Structure of Human Liver 4-3-Ketosteroid 5 -Reductase (AKR1D1) and Implications for Substrate Binding and CatalysisDevelopment of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate CancerCrystal Structure of Perakine Reductase, Founding Member of a Novel Aldo-Keto Reductase (AKR) Subfamily That Undergoes Unique Conformational Changes during NADPH BindingConversion of Human Steroid 5 -Reductase (AKR1D1) into 3 -Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERINGThree-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamilySteroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenaseStructure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3)Synthesis and evaluation of non-steroidal mechanism-based inactivators of 3 alpha-hydroxysteroid dehydrogenaseUnique patterns of molecular profiling between human prostate cancer LNCaP and PC-3 cellsMechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative diseaseEnvironmental health research recommendations from the Inter-Environmental Health Sciences Core Center Working Group on unconventional natural gas drilling operationsAnatomical and cellular localization of neuroactive 5 alpha/3 alpha-reduced steroid-synthesizing enzymes in the spinal cordPotential Metabolic Activation of a Representative C2-Alkylated Polycyclic Aromatic Hydrocarbon 6-Ethylchrysene Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) CellsHuman aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbonsInterception of benzo[a]pyrene-7,8-dione by UDP glucuronosyltransferases (UGTs) in human lung cellsSynthesis of (13)C4-labelled oxidized metabolites of the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyreneSynthesis of (13)C2-Benzo[a]pyrene and its 7,8-Dihydrodiol and 7,8-Dione Implicated as Carcinogenic MetabolitesQuantitation of benzo[a]pyrene metabolic profiles in human bronchoalveolar (H358) cells by stable isotope dilution liquid chromatography-atmospheric pressure chemical ionization mass spectrometryThe Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-QuinonesDetoxication of benzo[a]pyrene-7,8-dione by sulfotransferases (SULTs) in human lung cellsMetabolism and distribution of benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) in human lung cells by liquid chromatography tandem mass spectrometry: detection of an adenine B[a]P-7,8-dione adductDetoxication of structurally diverse polycyclic aromatic hydrocarbon (PAH) o-quinones by human recombinant catechol-O-methyltransferase (COMT) via O-methylation of PAH catecholsAryl hydrocarbon receptor facilitates DNA strand breaks and 8-oxo-2'-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dioneEvidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cellsOverexpression and mutagenesis of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. Role of cysteines and tyrosines in catalysis.Synthesis and characterization of polycyclic aromatic hydrocarbon o-quinone depurinating N7-guanine adducts.A bioactive metabolite of benzo[a]pyrene, benzo[a]pyrene-7,8-dione, selectively alters microsomal Ca2+ transport and ryanodine receptor function.Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer.Liquid chromatography-mass spectrometry (LC-MS) of steroid hormone metabolites and its applications.Integration of steroid research: perspectives on environment factors, homeostasis in health, and disease treatment.Metabolism of a representative oxygenated polycyclic aromatic hydrocarbon (PAH) phenanthrene-9,10-quinone in human hepatoma (HepG2) cells.Molecular determinants of steroid recognition and catalysis in aldo-keto reductases. Lessons from 3alpha-hydroxysteroid dehydrogenase.
P50
Q23910374-691360F5-5ABE-4D49-9661-CBE8F2A278E4Q24620663-2799EB50-73CC-4810-8006-D35A71B23F6AQ24657837-0CE4D677-7391-456B-8DF1-3FDF4DA8D6FBQ24658019-5669052A-A4E2-48A2-A502-2B98C93A67C0Q24679336-8B1CEFC0-ED5B-4FAE-ADEC-458C7C300001Q27026044-D9EFFA00-DD92-4282-AC8C-074BB2214054Q27313709-A2DE4AC8-3A1E-4B7A-8F05-EBD825224BDBQ27634228-63161EC2-73F0-4CB2-B4F6-57189916CC82Q27650311-9254E778-BBA0-4438-BE0B-EF3C33AC355BQ27676555-E0E09898-8E36-45E1-97C9-490F3EE905D7Q27677286-7DAEA853-35BD-4CB1-97D7-8E0F0D2CB153Q27678144-0C751D1E-C90F-484A-9512-A38039982841Q27731273-C649DB10-0845-4D5C-8F56-ED28B27224CDQ27741876-9FF3AECA-2159-42F1-890B-48F2AC2F6A13Q28199570-9A4BBA44-0D49-47C7-AE7D-3E433F67675CQ28354510-AD1C6B98-C2B7-48CB-B571-1FD3C6F667A1Q28391298-1303DABC-33FE-466C-8303-4F2F8FC90DB2Q28394732-5DDAC630-30B6-4957-98A2-04EAE77A39E6Q28396928-B75A12F9-93A4-48F4-8971-911C284B5751Q28569789-4F457C3F-2C6A-41BA-8EF6-9E5387840C9BQ28600891-930F0A18-C10E-4A3B-A3D1-EB68C85B1CF9Q28651791-9EB9685B-50B5-491D-8920-7469EF8FB79BQ28661585-46FFA4C5-2D26-418F-B243-B2F6956D61CAQ28661632-0B40A917-7B60-4D86-BD2F-AC246C2DD4F4Q28662277-59CFC384-7AA0-4865-8A0E-C3276D875182Q28672801-0A36C58C-DA5E-47EC-8DB3-0E8B1FA322C0Q28712007-72459277-4601-4F2D-A061-10B19654F739Q28727989-641A776F-60B7-4FF4-8F67-5DA7AC3EB8E0Q28729736-A8A1CA7D-19E9-4541-971D-2A9CA9A2EFB5Q28742535-F4C27BBE-A90B-4AC2-86C2-EE03FE5AE9B2Q28749699-77367943-9BAF-41BA-AD59-7324F60F0ABDQ28754574-73F41020-2AB6-4B2F-B084-790F6BAF069FQ30194354-1819CCE9-0985-4833-9B05-928A766CE379Q30559610-112EC41F-FA36-40A8-B584-ED9FB53B7833Q31942055-4106C534-AC51-4455-B08F-9E38BA8FE140Q33235187-12673660-E77D-4E72-8B32-A28C29FB4011Q33444906-A9D6206F-78C3-47FB-81DF-2CB4BE075768Q33559411-206E6577-CCC0-4E5A-BA14-36077B8A26DCQ33638652-8B9505E8-C81D-4A53-B28C-9CE168B342EDQ33694970-8279E17F-F6E0-4601-A62F-EA8E3A1D2E4A
P50
description
hulumtues
@sq
researcher
@en
ricercatore
@it
wetenschapper
@nl
հետազոտող
@hy
name
Trevor M Penning
@ast
Trevor M Penning
@en
Trevor M Penning
@es
Trevor M Penning
@nl
Trevor M Penning
@sl
type
label
Trevor M Penning
@ast
Trevor M Penning
@en
Trevor M Penning
@es
Trevor M Penning
@nl
Trevor M Penning
@sl
prefLabel
Trevor M Penning
@ast
Trevor M Penning
@en
Trevor M Penning
@es
Trevor M Penning
@nl
Trevor M Penning
@sl
P214
P244
P106
P21
P214
P244
n2003005447
P31
P496
0000-0002-3937-1066
P735
P7859
lccn-n2003005447