High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I. Implications for T-cell receptor engagement and T-cell immunodominance.
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Epitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complexA T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I moleculeComplete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchyNatural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognitionConformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificityRational development of high-affinity T-cell receptor-like antibodiesGerm Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell ReceptorThe Structure and Stability of the Monomorphic HLA-G Are Influenced by the Nature of the Bound PeptideConstraints within major histocompatibility complex class I restricted peptides: Presentation and consequences for T-cell recognitionHard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptabilityAllelic polymorphism in the T cell receptor and its impact on immune responsesMHC Class I Bound to an Immunodominant Theileria parva Epitope Demonstrates Unconventional Presentation to T Cell ReceptorsTwo Distinct Conformations of a Rinderpest Virus Epitope Presented by Bovine Major Histocompatibility Complex Class I N*01801: a Host Strategy To Present Featured PeptidesPeptide length determines the outcome of TCR/peptide-MHCI engagementHighly Divergent T-cell Receptor Binding Modes Underlie Specific Recognition of a Bulged Viral Peptide bound to a Human Leukocyte Antigen Class I MoleculeThe Energetic Basis Underpinning T-cell Receptor Recognition of a Super-bulged Peptide Bound to a Major Histocompatibility Complex Class I MoleculeStructural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptorA Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen MicropolymorphismComputational prediction of Usutu virus E protein B-cell and T-cell epitopes for potential vaccine developmentUnconventional Peptide Presentation by Major Histocompatibility Complex (MHC) Class I Allele HLA-A*02:01: BREAKING CONFINEMENT.Mass spectral data for 64 eluted peptides and structural modeling define peptide binding preferences for class I alleles in two chicken MHC-B haplotypes associated with opposite responses to Marek's diseaseTwo HLA-B14 subtypes (B*1402 and B*1403) differentially associated with ankylosing spondylitis differ substantially in peptide specificity but have limited peptide and T-cell epitope sharing with HLA-B27.Assembly and intracellular trafficking of HLA-B*3501 and HLA-B*3503Computer aided selection of candidate vaccine antigens.Identification of peptides from foot-and-mouth disease virus structural proteins bound by class I swine leukocyte antigen (SLA) alleles, SLA-1*0401 and SLA-2*0401.In vivo 6-thioguanine-resistant T cells from melanoma patients have public TCR and share TCR beta amino acid sequences with melanoma-reactive T cellsNaturally processed non-canonical HLA-A*02:01 presented peptides.Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer PeptideIdentification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors.A single amino acid difference within the alpha-2 domain of two naturally occurring equine MHC class I molecules alters the recognition of Gag and Rev epitopes by equine infectious anemia virus-specific CTL.A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.Localization of CD8 T cell epitope within cardiac myosin heavy chain-α334-352 that induces autoimmune myocarditis in A/J miceRecognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells.The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation.The Length Distribution of Class I-Restricted T Cell Epitopes Is Determined by Both Peptide Supply and MHC Allele-Specific Binding Preference.Toxoplasma gondii peptide ligands open the gate of the HLA class I binding grooveStructural determinants of T-cell receptor bias in immunity.Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity.Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.The versatility of the αβ T-cell antigen receptor.
P2860
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P2860
High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I. Implications for T-cell receptor engagement and T-cell immunodominance.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
High resolution structures of ...... nt and T-cell immunodominance.
@en
type
label
High resolution structures of ...... nt and T-cell immunodominance.
@en
prefLabel
High resolution structures of ...... nt and T-cell immunodominance.
@en
P2093
P2860
P50
P356
P1476
High resolution structures of ...... nt and T-cell immunodominance.
@en
P2093
Diah El-Hassen
Fleur E Tynan
Lars Kjer-Nielsen
Sharon L Silins
Wendy J M van Zuylen
P2860
P304
23900-23909
P356
10.1074/JBC.M503060200
P407
P50
P577
2005-04-22T00:00:00Z