The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci.
about
Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylationA guide for functional analysis of BRCA1 variants of uncertain significanceThe BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular LocationsBeyond DNA: An Integrated and Functional Approach for Classifying Germline Variants in Breast Cancer GenesBRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradationAssessment of human Nter and Cter BRCA1 mutations using growth and localization assays in yeast.Rapid recruitment of BRCA1 to DNA double-strand breaks is dependent on its association with Ku80Mutations in the BRCT binding site of BRCA1 result in hyper-recombinationDepicting combinatorial complexity with the molecular interaction map notation.BRCA1 Circos: a visualisation resource for functional analysis of missense variants.BRCA1 is required for postreplication repair after UV-induced DNA damageIn Vitro Enhanced Sensitivity to Cisplatin in D67Y BRCA1 RING Domain Protein.Characterization of BRCA1 protein targeting, dynamics, and function at the centrosome: a role for the nuclear export signal, CRM1, and Aurora A kinase.Impact of RING and BRCT domain mutations on BRCA1 protein stability, localization and recruitment to DNA damage.MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage.Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?Mitochondrial localization, ELK-1 transcriptional regulation and growth inhibitory functions of BRCA1, BRCA1a, and BRCA1b proteinsRING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance.RAP80 responds to DNA damage induced by both ionizing radiation and UV irradiation and is phosphorylated at Ser 205.BRCA1 16 years later: DNA damage-induced BRCA1 shuttling.The in vivo dynamic organization of BRCA1-A complex proteins at DNA damage-induced nuclear foci.Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization.BARD1 translocation to mitochondria correlates with Bax oligomerization, loss of mitochondrial membrane potential, and apoptosis.E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1.Expression of cancer related BRCA1 missense variants decreases MMS-induced recombination in Saccharomyces cerevisiae without altering its nuclear localization.Mutational analysis of BRCA1 and BRCA2 genes in Peruvian families with hereditary breast and ovarian cancer.Genetic, functional, and histopathological evaluation of two C-terminal BRCA1 missense variants.
P2860
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P2860
The BRCA1 RING and BRCT domains cooperate in targeting BRCA1 to ionizing radiation-induced nuclear foci.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
The BRCA1 RING and BRCT domain ...... adiation-induced nuclear foci.
@en
type
label
The BRCA1 RING and BRCT domain ...... adiation-induced nuclear foci.
@en
prefLabel
The BRCA1 RING and BRCT domain ...... adiation-induced nuclear foci.
@en
P2860
P356
P1476
The BRCA1 RING and BRCT domain ...... adiation-induced nuclear foci.
@en
P2093
Beric R Henderson
Wendy W Y Au
P2860
P304
P356
10.1074/JBC.M408879200
P407
P577
2004-11-29T00:00:00Z