Locating ligand-binding sites in 7TM receptors by protein engineering.
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The impact of GPCR structures on pharmacology and structure-based drug designControlling signaling with a specifically designed Gi-coupled receptorA method for the prediction of GPCRs coupling specificity to G-proteins using refined profile Hidden Markov ModelsStructure modeling of all identified G protein-coupled receptors in the human genomeBiased and g protein-independent signaling of chemokine receptorsGeneric GPCR residue numbers - aligning topology maps while minding the gapsEvidence for a direct interaction between the penultimate aspartic acid of cholecystokinin and histidine 207, located in the second extracellular loop of the cholecystokinin B receptorMolecular pharmacology of the secretin receptorBiophysical methods to study ligand-receptor interactions of neuropeptide YA segment of five amino acids in the second extracellular loop of the cholecystokinin-B receptor is essential for selectivity of the peptide agonist gastrinCritical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptorsTyr115 is the key residue for determining agonist selectivity in the V1a vasopressin receptorSequence diversity and genomic organization of vomeronasal receptor genes in the mouseMolecular basis of V2 vasopressin receptor/Gs coupling selectivityStructure and function of serotonin G protein-coupled receptors.Conserved aromatic residues in the transmembrane region VI of the V1a vasopressin receptor differentiate agonist vs. antagonist ligand binding.Structurally related peptide agonist, partial agonist, and antagonist occupy a similar binding pocket within the cholecystokinin receptor. Rapid analysis using fluorescent photoaffinity labeling probes and capillary electrophoresis.Mining the gene repertoire and ESTs for G protein-coupled receptors with evolutionary perspective.Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptorSeven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Genetic transfer of a nonpeptide antagonist binding site to a previously unresponsive angiotensin receptorA proposed structure for transmembrane segment 7 of G protein-coupled receptors incorporating an asn-Pro/Asp-Pro motif.Virally encoded 7TM receptors.The sixth transmembrane domains of the human B1 and B2 bradykinin receptors are structurally compatible and involved in discriminating between subtype-selective agonists.Mutational analysis of the interaction of the N- and C-terminal ends of angiotensin II with the rat AT(1A) receptorIdentification and functional comparison of seven-transmembrane G-protein-coupled BILF1 receptors in recently discovered nonhuman primate lymphocryptoviruses.Molecular Architecture of G Protein-Coupled Receptors.Conformational changes of G protein-coupled receptors during their activation by agonist binding.Interaction of biphenylimidazole and imidazoleacrylic acid nonpeptide antagonists with valine 108 in TM III of the AT1 angiotensin receptorCCR5 coreceptor utilization involves a highly conserved arginine residue of HIV type 1 gp120.The second extracellular loop of alpha2A-adrenoceptors contributes to the binding of yohimbine analoguesMolecular requirements for inhibition of the chemokine receptor CCR8--probe-dependent allosteric interactions.Functional analysis of the murine cytomegalovirus chemokine receptor homologue M33: ablation of constitutive signaling is associated with an attenuated phenotype in vivo.Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor.Structure of a G-protein-coupling domain of a muscarinic receptor predicted by random saturation mutagenesis.Use of multidimensional fluorescence resonance energy transfer to establish the orientation of cholecystokinin docked at the type A cholecystokinin receptor.Purification and reconstitution of a recombinant human neurokinin-1 receptor.Role of the extracellular loops of G protein-coupled receptors in ligand recognition: a molecular modeling study of the human P2Y1 receptor.Impact of helix irregularities on sequence alignment and homology modeling of G protein-coupled receptors.
P2860
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P2860
Locating ligand-binding sites in 7TM receptors by protein engineering.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Locating ligand-binding sites in 7TM receptors by protein engineering.
@en
type
label
Locating ligand-binding sites in 7TM receptors by protein engineering.
@en
prefLabel
Locating ligand-binding sites in 7TM receptors by protein engineering.
@en
P1476
Locating ligand-binding sites in 7TM receptors by protein engineering
@en
P2093
Schwartz TW
P304
P356
10.1016/0958-1669(94)90054-X
P577
1994-08-01T00:00:00Z