Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors - Wikidata - thesis-toulmin - TriplyDB

Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors

Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors

http://www.wikidata.org/entity/Q40584535

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Down-regulation of CTLA-4 by HIV-1 Nef protein HIV related pulmonary arterial hypertension: epidemiology in Africa, physiopathology, and role of antiretroviral treatment Exosomes are unlikely involved in intercellular Nef transfer Risk of echocardiographic pulmonary hypertension in individuals with human immunodeficiency virus-hepatitis C virus coinfection.Paracrine modulation of CXCR4 by IGF-1 and VEGF: implications for choroidal neovascularization.Human Immunodeficiency virus type 1 Nef potently induces apoptosis in primary human brain microvascular endothelial cells via the activation of caspases Genetic characterization of HIV type 1 Nef-induced vesicle secretion HIV Nef-M1 Effects on Colorectal Cancer Growth in Tumor-induced Spleens and Hepatic Metastasis Pulmonary hypertension associated with HIV infection: pulmonary vascular disease: the global perspective Mechanisms of HIV-associated lymphocyte apoptosis: 2010 CD4+ T cell depletion in human immunodeficiency virus (HIV) infection: role of apoptosis.Human immunodeficiency virus-1 (HIV-1)-mediated apoptosis: new therapeutic targets.Nef inhibits glucose uptake in adipocytes and contributes to insulin resistance in human immunodeficiency virus type I infection.Construction of doxycyline-dependent mini-HIV-1 variants for the development of a virotherapy against leukemias Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release.HIV inhibits endothelial reverse cholesterol transport through impacting subcellular Caveolin-1 trafficking.Hallmarks of HIV-1 pathogenesis are modulated by Nef's Secretion Modification Region Viral strategies for evading antiviral cellular immune responses of the host.Validation of a novel secretion modification region (SMR) of HIV-1 Nef using cohort sequence analysis and molecular modeling.Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals.Activation/proliferation and apoptosis of bystander goat lymphocytes induced by a macrophage-tropic chimeric caprine arthritis encephalitis virus expressing SIV Nef.Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line.A comprehensive analysis of the naturally occurring polymorphisms in HIV-1 Vpr: potential impact on CTL epitopes Peptide-based identification of functional motifs and their binding partners.Human immunodeficiency virus viral protein R as an extracellular protein in neuropathogenesis.Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques.Human immunodeficiency virus and pulmonary arterial hypertension.Genomics of pulmonary arterial hypertension: implications for therapy.HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells.High levels of anti-Nef antibodies may prevent AIDS disease progression in vertically HIV-1-infected infants.Imaging CXCR4 signaling with firefly luciferase complementation.Secretion modification region-derived peptide blocks exosome release and mediates cell cycle arrest in breast cancer cells.Viral infection and pulmonary hypertension: is there an association?Apoptotic peptides derived from HIV-1 Nef induce lymphocyte depletion in mice HIV-1 Nef promotes migration and chemokine synthesis of human basophils and mast cells through the interaction with CXCR4.HIV-1 Nef and T-cell activation: a history of contradictions.HIV Type 1 Nef is released from infected cells in CD45(+) microvesicles and is present in the plasma of HIV-infected individuals.HIV-1 Nef protein is secreted into vesicles that can fuse with target cells and virions.Characterization of Nef-CXCR4 interactions important for apoptosis induction.

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Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors

http://www.wikidata.org/entity/Q40584535

description

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Extracellular Nef protein targ ...... g with CXCR4 surface receptors

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Extracellular Nef protein targ ...... g with CXCR4 surface receptors

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JVI.78.6.3099-3109.2004

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Journal of Virology

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Extracellular Nef protein targ ...... g with CXCR4 surface receptors

@en

P2093

Cleve O James

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Mafuz Khan

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Michael D Powell

http://www.w3.org/2001/XMLSchema#string

Minerva Garcia-Barrio

http://www.w3.org/2001/XMLSchema#string

Ming-Bo Huang

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Vincent C Bond

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P2860

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases

Involvement of chemokine receptors in breast cancer metastasis

HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis.

Caspases: the executioners of apoptosis

HIV-1 Tat protein mimicry of chemokines

Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity

Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain

HIV-Tat dependent chemotaxis and invasion, key aspects of tat mediated pathogenesis

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3099-3109

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10.1128/JVI.78.6.3099-3109.2004

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353732

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