The chemokine receptor CXCR4 enhances integrin-mediated in vitro adhesion and facilitates engraftment of leukemic precursor-B cells in the bone marrow.
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Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapyAdvances in understanding the leukaemia microenvironmentTransfection of antisense core 2 beta1,6-N-acetylglucosaminyltransferase-1 cDNA suppresses selectin ligand expression and tissue infiltration of B-cell precursor leukemia cellsMLL-rearranged acute lymphoblastic leukaemia stem cell interactions with bone marrow stroma promote survival and therapeutic resistance that can be overcome with CXCR4 antagonismIn vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftmentAMD3100 plus G-CSF can successfully mobilize CD34+ cells from non-Hodgkin's lymphoma, Hodgkin's disease and multiple myeloma patients previously failing mobilization with chemotherapy and/or cytokine treatment: compassionate use data.Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells.Mouse xenograft modeling of human adult acute lymphoblastic leukemia provides mechanistic insights into adult LIC biology.A designed peptide targeting CXCR4 displays anti-acute myelocytic leukemia activity in vitro and in vivo.Plerixafor as a chemosensitizing agent in pediatric acute lymphoblastic leukemia: efficacy and potential mechanisms of resistance to CXCR4 inhibition.Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide.Homing and mobilization of hematopoietic stem cells and hematopoietic cancer cells are mirror image processes, utilizing similar signaling pathways and occurring concurrently: circulating cancer cells constitute an ideal target for concurrent treatmRegulation of lymphoid and myeloid leukemic cell survival: role of stromal cell adhesion molecules.Hierarchy of molecular-pathway usage in bone marrow homing and its shift by cytokines.IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomesExpression of SOCS1 and CXCL12 Proteins in Primary Breast Cancer Are Associated with Presence of Circulating Tumor Cells in Peripheral BloodEffects of AMD3100 on transmigration and survival of acute myelogenous leukemia cellsPOL5551, a novel and potent CXCR4 antagonist, enhances sensitivity to chemotherapy in pediatric ALLThe CXCR4 chemokine receptor in acute and chronic leukaemia: a marrow homing receptor and potential therapeutic target.Effectiveness of AMD3100 in treatment of leukemia and solid tumors: from original discovery to use in current clinical practice.Emerging targets in cancer management: role of the CXCL12/CXCR4 axis.Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.The critical role of SDF-1/CXCR4 axis in cancer and cancer stem cells metastasis.Novel postremission strategies in adults with acute myeloid leukemia.Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches.Pro-inflammatory-Related Loss of CXCL12 Niche Promotes Acute Lymphoblastic Leukemic Progression at the Expense of Normal Lymphopoiesis.The bone marrow microenvironment and leukemia: biology and therapeutic targeting.Mobilization of hematopoietic stem and leukemia cells.Pharmacogenomic considerations of xenograft mouse models of acute leukemia.Regulation of hematopoietic and leukemic stem cells by the immune system.CXCL12/CXCR4 axis in the pathogenesis of acute lymphoblastic leukemia (ALL): a possible therapeutic target.Cell adhesion manipulation through single cell assembly for characterization of initial cell-to-cell interaction.Treatment of acute lymphoblastic leukemia with an rGel/BLyS fusion toxin.A Lentiviral CXCR4 overexpression and knockdown model in colorectal cancer cell lines reveals plerixafor-dependent suppression of SDF-1α-induced migration and invasion.Cellular elements of the subarachnoid space promote ALL survival during chemotherapy.Pertussis toxin inhibits neutrophil recruitment to delay antibody-mediated clearance of Bordetella pertussis.Myosin-IIA regulates leukemia engraftment and brain infiltration in a mouse model of acute lymphoblastic leukemia.The SDF-1 G > A polymorphism at position 801 plays no role in multiple myeloma but may contribute to an inferior cause-specific survival in chronic lymphocytic leukemia.Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells.CCR7 and CXCR4 Expression in Primary Head and Neck Squamous Cell Carcinomas and Nodal Metastases – a Clinical and Immunohistochemical Study
P2860
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P2860
The chemokine receptor CXCR4 enhances integrin-mediated in vitro adhesion and facilitates engraftment of leukemic precursor-B cells in the bone marrow.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
The chemokine receptor CXCR4 e ...... or-B cells in the bone marrow.
@en
type
label
The chemokine receptor CXCR4 e ...... or-B cells in the bone marrow.
@en
prefLabel
The chemokine receptor CXCR4 e ...... or-B cells in the bone marrow.
@en
P2093
P1476
The chemokine receptor CXCR4 e ...... sor-B cells in the bone marrow
@en
P2093
K F Bradstock
L J Bendall
P304
P356
10.1016/S0301-472X(01)00741-X
P577
2001-12-01T00:00:00Z