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LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptorSerotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disordersIdentification of a red-emitting fluorescent ligand for in vitro visualization of human serotonin 5-HT(1A) receptors.Design, synthesis, radiolabeling, and in vivo evaluation of carbon-11 labeled N-[2-[4-(3-cyanopyridin-2-yl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a potential positron emission tomography tracer for the dopamine D(4) receptorsStructure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.Interplay between serotonin 5-HT1A and 5-HT7 receptors in depressive disorders.Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.Prepuberal stimulation of 5-HT7-R by LP-211 in a rat model of hyper-activity and attention-deficit: permanent effects on attention, brain amino acids and synaptic markers in the fronto-striatal interface.Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndromeML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth.Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 23-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: molecular modeling of chiral recognition by FPR25-HT1A receptor, an old target for new therapeutic agents.Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in miceDevelopments in fluorescent probes for receptor research.5-HT(7) receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009).The therapeutic potential of 5-HT1A receptors: a patent review.Modulatory effects following subchronic stimulation of brain 5-HT7-R system in mice and rats.Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview.The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling.Analogues of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers.Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: synthesis and binding affinities for 5-HT(7) and 5-HT(1A) receptors.Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors.Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands.Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D(3) receptor ligands.Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics.Differential responses to acute administration of a new 5-HT7-R agonist as a function of adolescent pre-treatment: phMRI and immuno-histochemical study.The brain-penetrant 5-HT7 receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain.Pharmacological stimulation of the brain serotonin receptor 7 as a novel therapeutic approach for Rett syndrome.Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome.Increase of capsaicin-induced trigeminal Fos-like immunoreactivity by 5-HT(7) receptors.Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in Naples High Excitability rats.Synthesis and characterization of environment-sensitive fluorescent ligands for human 5-HT1A receptors with 1-arylpiperazine structure.trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT(1A) receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines.N-[omega-[4-(2-methoxyphenyl)-1-piperazinyl]alkyl]-2-quinolinamines as high-affinity fluorescent 5-HT1A receptor ligands.Determination of 1-aryl-4-propylpiperazine pKa values: the substituent on aryl modulates basicity.Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II.Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress.Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III.Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome.
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description
hulumtuese
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onderzoeker
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researcher
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հետազոտող
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name
Enza Lacivita
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Enza Lacivita
@en
Enza Lacivita
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Enza Lacivita
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Enza Lacivita
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Enza Lacivita
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Enza Lacivita
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Enza Lacivita
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Enza Lacivita
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Enza Lacivita
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Enza Lacivita
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Enza Lacivita
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Enza Lacivita
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Enza Lacivita
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Enza Lacivita
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P106
P1153
6507113380
P21
P31
P4012
P496
0000-0003-2443-1174