Identification of binding sites in the nicotinic acetylcholine receptor for TDBzl-etomidate, a photoreactive positive allosteric effector
about
The positive allosteric modulator morantel binds at noncanonical subunit interfaces of neuronal nicotinic acetylcholine receptorsAnesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptorsInteractions of L-3,5,3'-Triiodothyronine [corrected], Allopregnanolone, and Ivermectin with the GABAA Receptor: Evidence for Overlapping Intersubunit Binding ModesExploring volatile general anesthetic binding to a closed membrane-bound bacterial voltage-gated sodium channel via computationNMR structures of the transmembrane domains of the α4β2 nAChRMapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogueMolecular mechanism for the dual alcohol modulation of Cys-loop receptorsPhotoaffinity Labeling of Pentameric Ligand-Gated Ion Channels: A Proteomic Approach to Identify Allosteric Modulator Binding Sites.Higher susceptibility to halothane modulation in open- than in closed-channel alpha4beta2 nAChR revealed by molecular dynamics simulationsConformational changes in the nicotinic acetylcholine receptor during gating and desensitizationAnesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel.Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain.Anesthetic binding in a pentameric ligand-gated ion channel: GLICRecognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis.Specificity determinants of allosteric modulation in the neuronal nicotinic acetylcholine receptor: a fine line between inhibition and potentiationMultiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.General anesthetics predicted to block the GLIC pore with micromolar affinity.Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog.Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels.p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels.Desformylflustrabromine (dFBr) and [3H]dFBr-Labeled Binding Sites in a Nicotinic Acetylcholine Receptor.Bupropion binds to two sites in the Torpedo nicotinic acetylcholine receptor transmembrane domain: a photoaffinity labeling study with the bupropion analogue [(125)I]-SADU-3-72.Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.NMR resolved multiple anesthetic binding sites in the TM domains of the α4β2 nAChRCommon Anesthetic-binding Site for Inhibition of Pentameric Ligand-gated Ion Channelsp-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol.Photolabeling a Nicotinic Acetylcholine Receptor (nAChR) with an (α4)3(β2)2 nAChR-Selective Positive Allosteric Modulator.Time-resolved photolabeling of the nicotinic acetylcholine receptor by [3H]azietomidate, an open-state inhibitor.General anesthetic binding to neuronal alpha4beta2 nicotinic acetylcholine receptor and its effects on global dynamicsMechanisms revealed through general anesthetic photolabeling.Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.Identifying barbiturate binding sites in a nicotinic acetylcholine receptor with [3H]allyl m-trifluoromethyldiazirine mephobarbital, a photoreactive barbiturate.Photoaffinity labeling of nicotinic receptors: diversity of drug binding sites!Shedding Light on Anesthetic Mechanisms: Application of Photoaffinity Ligands.Identification of a putative binding site critical for general anesthetic activation of TRPA1.Nicotinic acetylcholine receptors at the single-channel level.[(3)H]chlorpromazine photolabeling of the torpedo nicotinic acetylcholine receptor identifies two state-dependent binding sites in the ion channel.Physostigmine and galanthamine bind in the presence of agonist at the canonical and noncanonical subunit interfaces of a nicotinic acetylcholine receptor.Multiple transmembrane binding sites for p-trifluoromethyldiazirinyl-etomidate, a photoreactive Torpedo nicotinic acetylcholine receptor allosteric inhibitor.Enantiomeric barbiturates bind distinct inter- and intrasubunit binding sites in a nicotinic acetylcholine receptor (nAChR).
P2860
Q24651488-D84ABDB7-DA3D-4590-847E-A41EBC97A747Q26824325-0F8BDE57-B5B2-497E-9EBD-491C69495AAFQ27316335-0D5D3E6C-654F-47BD-A830-58745D051FFBQ27324485-F610492C-F98A-4CDB-B685-61AB627FE773Q27677442-4BA1F5AA-724E-44FA-B04F-AE1BF6B9D642Q28257428-00F816F9-0FC0-423C-8495-9B1DBABA979EQ28484223-5165BB59-1A42-41CB-AE28-73B939A78248Q30402002-20ACE651-DC81-40EC-9F8D-4BDCA32C91A4Q33586364-EE023CCA-25EF-4103-9EDD-E26B9979019BQ33639177-36422B10-E5B7-43DD-86C4-491BE9340B17Q33962539-F9570FBF-7DAE-407F-A700-6D31E8415782Q34069441-A0822B0B-EB2C-428A-BBAD-68E148B4C244Q34134631-D17E6B40-01AF-4E7B-8067-3814EC0D2B83Q34168547-85C328D8-3096-4812-A63D-AAE14D734079Q34230674-E7C9B859-76FA-48CD-8A1A-9C3554158ABEQ34283376-CDB295A6-BC92-45F6-888E-E0DA6709EB42Q34302137-383921CE-3773-48CA-A14F-A0C7DAF53208Q34660993-7ACE37B5-D90D-4F50-8A56-DCCEBF73BF79Q35024917-83710406-742B-4CE3-9EE9-93A9687E8A29Q35052026-0F6F0562-2B94-403C-A68B-094EA87389DEQ35745950-18C62338-5C40-4F56-8544-E19C7FF93880Q35860186-448F3C1C-EA73-4A84-A9C6-29FD647AB5A9Q36034016-F3F09081-35A9-4792-862C-B7702E92DE2DQ36501779-8A3992DE-AB5F-4E50-9882-15C73F4F3CA2Q36586214-78382A65-88CB-429C-803D-CFE181CC4A4BQ36634576-A29915CF-D50C-4208-8BE4-5ADDFE39D9CFQ36852497-9B3A9CD7-AF8A-4524-96EF-4F9C0649E6D5Q37168387-F32664CC-180A-4F7D-948F-77F886C0A813Q37358834-162D3F3E-1713-41D2-818E-3B80A5317780Q37590817-6C577240-1EBA-450E-805D-7AEA7E836C06Q37680855-F0FF2C20-3355-45DF-ABC9-260742ABB169Q37708111-237C72F8-6B6C-4BCD-B7D1-25D02CF17EAAQ38155454-E995DB97-971F-4462-B588-27929D02D6A2Q38809648-2BC57D55-5BD6-4FF8-8439-3C065BB209DFQ38892415-FAAAD04D-98C5-4E06-8085-E6C482CB2EA5Q39162936-B864B6CB-833E-4DFE-B914-77063E1DAFDDQ40818014-90CC4F76-DD74-46A5-A9EA-560A6D32C297Q41822635-6FD6210E-E4C1-4CAE-8DE5-2583A554C358Q42042184-5BBBC4DB-7B8D-4777-8290-08D7A77800F9Q47255862-3D4FA79E-C92D-433D-AA53-05CE4788019B
P2860
Identification of binding sites in the nicotinic acetylcholine receptor for TDBzl-etomidate, a photoreactive positive allosteric effector
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Identification of binding site ...... e positive allosteric effector
@en
type
label
Identification of binding site ...... e positive allosteric effector
@en
prefLabel
Identification of binding site ...... e positive allosteric effector
@en
P2093
P2860
P356
P1476
Identification of binding site ...... e positive allosteric effector
@en
P2093
David C Chiara
Galo Garcia
Jonathan B Cohen
S Shaukat Husain
Selvanayagam Nirthanan
P2860
P304
22051-22062
P356
10.1074/JBC.M801332200
P407
P577
2008-06-04T00:00:00Z