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Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome.Domain analysis of Kv6.3, an electrically silent channelA polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierolConserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels.Evidence for multiple open and inactivated states of the hKv1.5 delayed rectifierDifferential modulation of Kv4 kinetics by KCHIP1 splice variants.The electrically silent Kv6.4 subunit confers hyperpolarized gating charge movement in Kv2.1/Kv6.4 heterotetrameric channels.KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.The subfamily-specific interaction between Kv2.1 and Kv6.4 subunits is determined by interactions between the N- and C-termini.A rapidly activating and slowly inactivating potassium channel cloned from human heart. Functional analysis after stable mammalian cell culture expressionK+ currents and K+ channel mRNA in cultured atrial cardiac myocytes (AT-1 cells).Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels.Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking.Being flexible: the voltage-controllable activation gate of kv channels.Voltage-sensor conformation shapes the intra-membrane drug binding site that determines gambierol affinity in Kv channels.A Kv channel with an altered activation gate sequence displays both "fast" and "slow" activation kinetics.Modulation of HERG gating by a charge cluster in the N-terminal proximal domain.Purification, molecular cloning and functional characterization of HelaTx1 (Heterometrus laoticus): the first member of a new κ-KTX subfamilyHERG mutation predicts short QT based on channel kinetics but causes long QT by heterotetrameric trafficking deficiency.Mutations throughout the S6 region of the hKv1.5 channel alter the stability of the activation gate.Rapid inactivation determines the rectification and [K+]o dependence of the rapid component of the delayed rectifier K+ current in cardiac cells.High affinity open channel block by dofetilide of HERG expressed in a human cell line.Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects.The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closureKv3.3b expression defines the shape of the complex spike in the Purkinje cell.Functional expression of an inactivating potassium channel cloned from human heart.Kv2.1 and silent Kv subunits underlie the delayed rectifier K+ current in cultured small mouse DRG neuronsDual effect of phosphatidylinositol (4,5)-bisphosphate PIP(2) on Shaker K(+) [corrected] channelsMolecular determinants of stereoselective bupivacaine block of hKv1.5 channels.Molecular analysis of a binding site for quinidine in a human cardiac delayed rectifier K+ channel. Role of S6 in antiarrhythmic drug binding.Role of the S6 C-terminus in KCNQ1 channel gating.Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes.Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers.Kv channel gating requires a compatible S4-S5 linker and bottom part of S6, constrained by non-interacting residues.Effects of a quaternary bupivacaine derivative on delayed rectifier K(+) currentsEffects of antiarrhythmic drugs on cloned cardiac voltage-gated potassium channels expressed in Xenopus oocytes.Drug block of I(kr): model systems and relevance to human arrhythmias.Gating of shaker-type channels requires the flexibility of S6 caused by prolines.Class III antiarrhythmic effects of zatebradine. Time-, state-, use-, and voltage-dependent block of hKv1.5 channels.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Dirk J Snyders
@ast
Dirk J Snyders
@en
Dirk J Snyders
@es
Dirk J Snyders
@sl
type
label
Dirk J Snyders
@ast
Dirk J Snyders
@en
Dirk J Snyders
@es
Dirk J Snyders
@sl
prefLabel
Dirk J Snyders
@ast
Dirk J Snyders
@en
Dirk J Snyders
@es
Dirk J Snyders
@sl
P1053
A-2713-2013
P106
P21
P31
P3829
P496
0000-0001-7142-6672