about
Do fish perceive anaesthetics as aversive?Individuals Maintain Similar Rates of Protein Synthesis over Time on the Same Plane of Nutrition under Controlled Environmental ConditionsQuantitative cross-species extrapolation between humans and fish: the case of the anti-depressant fluoxetineThe First Attempt at Non-Linear in Silico Prediction of Sampling Rates for Polar Organic Chemical Integrative Samplers (POCIS)Climate change and pollution speed declines in zebrafish populationsUsing data from drug discovery and development to aid the aquatic environmental risk assessment of human pharmaceuticals: concepts, considerations, and challenges.Effects of the lipid regulating drug clofibric acid on PPARĪ±-regulated gene transcript levels in common carp (Cyprinus carpio) at pharmacological and environmental exposure levels.Functional xenobiotic metabolism and efflux transporters in trout hepatocyte spheroid cultures.Direct Measurements of Oxygen Gradients in Spheroid Culture System Using Electron Parametric Resonance Oximetry.The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment.Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish.Comparative physiology, pharmacology and toxicology of beta-blockers: mammals versus fish.Assessing the reliability of uptake and elimination kinetics modelling approaches for estimating bioconcentration factors in the freshwater invertebrate, Gammarus pulex.Testing the "read-across hypothesis" by investigating the effects of ibuprofen on fishGenetic variation, inbreeding and chemical exposure--combined effects in wildlife and critical considerations for ecotoxicology.Pharmaceutical Metabolism in Fish: Using a 3-D Hepatic In Vitro Model to Assess Clearance.Differences in sexual development in inbred and outbred zebrafish (Danio rerio) and implications for chemical testing.Application of the rainbow trout derived intestinal cell line (RTgutGC) for ecotoxicological studies: molecular and cellular responses following exposure to copper.Towards a more representative in vitro method for fish ecotoxicology: morphological and biochemical characterisation of three-dimensional spheroidal hepatocytes.Uptake, biotransformation and elimination of selected pharmaceuticals in a freshwater invertebrate measured using liquid chromatography tandem mass spectrometry.4-dimensional functional profiling in the convulsant-treated larval zebrafish brain.Species specific anaesthetics for fish anaesthesia and euthanasia.Pharmaceuticals in the freshwater invertebrate, Gammarus pulex, determined using pulverised liquid extraction, solid phase extraction and liquid chromatography-tandem mass spectrometry.A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: evidence for passive and facilitated transport.Correction: Direct Measurements of Oxygen Gradients in Spheroid Culture System Using Electron Parametric Resonance Oximetry.Corrigendum: Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish.In vivo and in vitro liver and gill EROD activity in rainbow trout (Oncorhynchus mykiss) exposed to the beta-blocker propranolol.The read-across hypothesis and environmental risk assessment of pharmaceuticals.The value of repeating studies and multiple controls: replicated 28-day growth studies of rainbow trout exposed to clofibric acid.In vitro models of xenobiotic metabolism in trout for use in environmental bioaccumulation studies.Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs.Uptake of propranolol, a cardiovascular pharmaceutical, from water into fish plasma and its effects on growth and organ biometry.A multi-endpoint in vivo larval zebrafish (Danio rerio) model for the assessment of integrated cardiovascular function.International survey on the use and welfare of zebrafish Danio rerio in research.High-Content and Semi-Automated Quantification of Responses to Estrogenic Chemicals Using a Novel Translucent Transgenic Zebrafish.Establishment and long-term maintenance of primary intestinal epithelial cells cultured from the rainbow trout, Oncorhynchus mykiss.Are toxicological responses in laboratory (inbred) zebrafish representative of those in outbred (wild) populations? - A case study with an endocrine disrupting chemical.Procedures for the reconstruction, primary culture and experimental use of rainbow trout gill epithelia.Bioavailability of the imidazole antifungal agent clotrimazole and its effects on key biotransformation genes in the common carp (Cyprinus carpio)
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P50
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hulumtues
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researcher
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Õ°Õ„ÕæÕ”Õ¦ÕøÕæÕøÕ²
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Stewart F. Owen
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Stewart F. Owen
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Stewart F. Owen
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Stewart F. Owen
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Stewart F. Owen
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Stewart F. Owen
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Stewart F. Owen
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Stewart F. Owen
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Stewart F. Owen
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Stewart F. Owen
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Stewart F. Owen
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Stewart F. Owen
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Stewart F. Owen
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Stewart F. Owen
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Stewart F. Owen
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P1153
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P21
P31
P496
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