Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake.
about
Changes in the Factor VIII C2 domain upon membrane binding determined by hydrogen-deuterium exchange MS.Applications of hydrogen/deuterium exchange MS from 2012 to 2014.The 1.7 Å X-ray crystal structure of the porcine factor VIII C2 domain and binding analysis to anti-human C2 domain antibodies and phospholipid surfacesFactor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising "Hot-Spot" Lysine Residues.High-affinity, noninhibitory pathogenic C1 domain antibodies are present in patients with hemophilia A and inhibitors.The C1 and C2 domains of blood coagulation factor VIII mediate its endocytosis by dendritic cells.Current approaches to fine mapping of antigen-antibody interactions.Evidence That Factor VIII Forms a Bivalent Complex with the Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1): IDENTIFICATION OF CLUSTER IV ON LRP1 AS THE MAJOR BINDING SITE.High-affinity von Willebrand factor binding does not affect the anatomical or hepatocellular distribution of factor VIII in rats.Molecular design and downstream processing of turoctocog alfa (NovoEight), a B-domain truncated factor VIII molecule.Membrane Interaction of the Factor VIIIa Discoidin Domains in Atomistic Detail.Inhibitory antibodies against factor VIII C1 domain.Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry.Factor VIII/V C-domain swaps reveal discrete C-domain roles in factor VIII function and intracellular trafficking.Molecular mechanisms of missense mutations that generate ectopic N-glycosylation sites in coagulation factor VIII.
P2860
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P2860
Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Factor VIII C1 domain spikes 2 ...... function and cellular uptake.
@en
type
label
Factor VIII C1 domain spikes 2 ...... function and cellular uptake.
@en
prefLabel
Factor VIII C1 domain spikes 2 ...... function and cellular uptake.
@en
P2093
P2860
P356
P1476
Factor VIII C1 domain spikes 2 ...... r function and cellular uptake
@en
P2093
Alexander B Meijer
Esther Bloem
Henning R Stennicke
Johan H Faber
Koen Mertens
Maartje van den Biggelaar
Marianne Kjalke
P2860
P304
29670-29679
P356
10.1074/JBC.M113.473116
P407
P577
2013-09-05T00:00:00Z