Role of oxidative stress in geldanamycin-induced cytotoxicity and disruption of Hsp90 signaling complex.
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Stress Regulates Aquaporin-8 Permeability to Impact Cell Growth and Survival.Apoptosis in response to heat stress is positively associated with heat-shock protein 90 expression in chicken myocardial cells in vitroHsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin inhibits the proliferation of ARPE-19 cells.Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells.Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptorsOverexpression of mitochondrial uncoupling protein 2 inhibits inflammatory cytokines and activates cell survival factors after cerebral ischemia.Thioredoxin-1 redox signaling regulates cell survival in response to hyperoxia.Hsp90 is cleaved by reactive oxygen species at a highly conserved N-terminal amino acid motif.HSP90 Inhibitor Geldanamycin as a Radiation Response Modificator in Human Blood CellsInduction of apoptosis by luteolin involving akt inactivation in human 786-o renal cell carcinoma cellsInvolvement of calcium-mediated reactive oxygen species in inductive GRP78 expression by geldanamycin in 9L rat brain tumor cellsStructure-activity relationship (SAR) of withanolides to inhibit Hsp90 for its activity in pancreatic cancer cells.Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo.Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assayβ-Lapachone Induces NAD(P)H:Quinone Oxidoreductase-1- and Oxidative Stress-Dependent Heat Shock Protein 90 Cleavage and Inhibits Tumor Growth and Angiogenesis.HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-κB pathways.Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development.
P2860
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P2860
Role of oxidative stress in geldanamycin-induced cytotoxicity and disruption of Hsp90 signaling complex.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Role of oxidative stress in ge ...... on of Hsp90 signaling complex.
@en
type
label
Role of oxidative stress in ge ...... on of Hsp90 signaling complex.
@en
prefLabel
Role of oxidative stress in ge ...... on of Hsp90 signaling complex.
@en
P2093
P2860
P1476
Role of oxidative stress in ge ...... on of Hsp90 signaling complex.
@en
P2093
Christina B Clark
Cynthia J Miller
Delphine El Mehdi
Evelyne Gozal
Leroy R Sachleben
Madhavi J Rane
P2860
P304
P356
10.1016/J.FREERADBIOMED.2009.08.012
P577
2009-08-21T00:00:00Z