Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate - Wikidata - thesis-toulmin - TriplyDB

Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate

Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate

http://www.wikidata.org/entity/Q42324155

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Recent advances in malaria drug discovery Biochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is active A chemical proteomics approach for the search of pharmacological targets of the antimalarial clinical candidate albitiazolium in Plasmodium falciparum using photocrosslinking and click chemistry Gametocytocidal screen identifies novel chemical classes with Plasmodium falciparum transmission blocking activity An Atypical Mitochondrial Carrier That Mediates Drug Action in Trypanosoma brucei Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite Death Plasmodium falciparum CTP:phosphocholine cytidylyltransferase possesses two functional catalytic domains and is inhibited by a CDP-choline analog selected from a virtual screening Antimalarial compounds in Phase II clinical development.Kinetic modelling of phospholipid synthesis in Plasmodium knowlesi unravels crucial steps and relative importance of multiple pathways.Molecular Mechanism for the Thermo-Sensitive Phenotype of CHO-MT58 Cell Line Harbouring a Mutant CTP:Phosphocholine Cytidylyltransferase Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexans New insight-guided approaches to detect, cure, prevent and eliminate malaria.High Accumulation and In Vivo Recycling of the New Antimalarial Albitiazolium Lead to Rapid Parasite Death.New insight into the mechanism of accumulation and intraerythrocytic compartmentation of albitiazolium, a new type of antimalarial.Development of the first oral bioprecursors of bis-alkylguanidine antimalarial drugs.Composite aromatic boxes for enzymatic transformations of quaternary ammonium substrates.Evolutionary and mechanistic insights into substrate and product accommodation of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum.Contribution of the precursors and interplay of the pathways in the phospholipid metabolism of the malaria parasite Structural determinants of the catalytic mechanism of Plasmodium CCT, a key enzyme of malaria lipid biosynthesis

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Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate

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Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate

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Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate

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Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate

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Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate

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Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate

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British Journal of Pharmacology

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Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate

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