about
The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGFThe elucidation of novel SH2 binding sites on PLD2IL-8-induced neutrophil chemotaxis is mediated by Janus kinase 3 (JAK3)A novel phospholipase D2-Grb2-WASp heterotrimer regulates leukocyte phagocytosis in a two-step mechanismMechanism of enzymatic reaction and protein-protein interactions of PLD from a 3D structural model.Short-hairpin RNA-mediated stable silencing of Grb2 impairs cell growth and DNA synthesisMammalian target of rapamycin (mTOR) and S6 kinase down-regulate phospholipase D2 basal expression and function.Phospholipase D in cell signaling: from a myriad of cell functions to cancer growth and metastasis.The molecular basis of leukocyte adhesion involving phosphatidic acid and phospholipase DThe uncovering of a novel regulatory mechanism for PLD2: formation of a ternary complex with protein tyrosine phosphatase PTP1B and growth factor receptor-bound protein GRB2.Cell invasion of highly metastatic MTLn3 cancer cells is dependent on phospholipase D2 (PLD2) and Janus kinase 3 (JAK3).Ribosomal p70S6K basal activity increases upon induction of differentiation of myelomonocytic leukemic cell lines HL60, AML14 and MPDEvidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2.The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxisThe exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF).Phospholipase D2 (PLD2) shortens the time required for myeloid leukemic cell differentiation: mechanism of actionPhosphatidic Acid Increases Epidermal Growth Factor Receptor Expression by Stabilizing mRNA Decay and by Inhibiting Lysosomal and Proteasomal Degradation of the Internalized ReceptorBiochemical and cellular implications of a dual lipase-GEF function of phospholipase D2 (PLD2).PLD-Specific Small-Molecule Inhibitors Decrease Tumor-Associated Macrophages and Neutrophils Infiltration in Breast Tumors and Lung and Liver Metastases.Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on RasIdentification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activityDown-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion.A Repertoire of MicroRNAs Regulates Cancer Cell Starvation by Targeting Phospholipase D in a Feedback Loop That Operates Maximally in Cancer CellsA new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cellsUnderstanding phospholipase D (PLD) using leukocytes: PLD involvement in cell adhesion and chemotaxis.A GEF-to-phospholipase molecular switch caused by phosphatidic acid, Rac and JAK tyrosine kinase that explains leukocyte cell migrationThe transcription factors Slug (SNAI2) and Snail (SNAI1) regulate phospholipase D (PLD) promoter in opposite ways towards cancer cell invasion.Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation.Macrophage migration arrest due to a winning balance of Rac2/Sp1 repression over β-catenin-induced PLD expressionPhosphatidic acid, phospholipase D and tumorigenesis.A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells.Human cell line that differentiates to all myeloid lineages and expresses neutrophil secondary granule genes.Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2.p42-MAP kinase is activated in EGF-stimulated interphase but not in metaphase-arrested HeLa cells.Presence of a phospholipase D (PLD) distinct from PLD1 or PLD2 in human neutrophils: immunobiochemical characterization and initial purification.Normal neutrophil maturation is associated with selective loss of MAP kinase activation by G-CSF.Thematic minireview series on phospholipase D and cancer.Mechanism of ribosomal p70S6 kinase activation by granulocyte macrophage colony-stimulating factor in neutrophils: cooperation of a MEK-related, THR421/SER424 kinase and a rapamycin-sensitive, m-TOR-related THR389 kinase.How miRs and mRNA deadenylases could post-transcriptionally regulate expression of tumor-promoting protein PLD.A systematic approach to the complete study of a signaling molecule: ribosomal p90rsk as an example.
P50
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P50
description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Julián Gómez-Cambronero
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Julián Gómez-Cambronero
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Julián Gómez-Cambronero
@en
Julián Gómez-Cambronero
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Julián Gómez-Cambronero
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Julián Gómez-Cambronero
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Julián Gómez-Cambronero
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Julián Gómez-Cambronero
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Julián Gómez-Cambronero
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Julián Gómez-Cambronero
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Julián Gómez-Cambronero
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Julián Gómez-Cambronero
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Julián Gómez-Cambronero
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Julián Gómez-Cambronero
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Julian G. Cambronero
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Julian Gomez-Cambronero
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Julián Gómez-Cambronero
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Julián Gómez-Cambronero
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Julián Gómez-Cambronero
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Julián Gómez-Cambronero
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Julián Gómez-Cambronero
@fr
Julián Gómez-Cambronero
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Julián Gómez-Cambronero
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P106
P1153
7003976799
P19
P1960
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P20
P2038
Julian_Gomez-Cambronero
P21
P213
0000 0003 7227 1160
P31
P496
0000-0002-7581-9227
P569
1959-09-29T00:00:00Z
P570
2018-11-12T00:00:00Z