Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system.
about
The contribution of intrinsically disordered regions to protein function, cellular complexity, and human diseaseDegrons of yeast and mammalian ornithine decarboxylase enzymes make potent combination for regulated targeted protein degradation.Variation in auxin sensing guides AUX/IAA transcriptional repressor ubiquitylation and destruction.Non-degradative Ubiquitination of Protein Kinases.Degradation elements coincide with cofactor binding sites in a short-lived transcription factor.Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitinationDevelopment of β-Hairpin Peptides for the Measurement of SCF-Family E3 Ligase Activity in Vitro via Ornithine Ubiquitination.Exploring the Sequence-based Prediction of Folding Initiation Sites in Proteins.Functions of intrinsic disorder in transmembrane proteins.SCFFBXO17 E3 ligase modulates inflammation by regulating proteasomal degradation of glycogen synthase kinase-3β in lung epithelia.Design Principles Involving Protein Disorder Facilitate Specific Substrate Selection and Degradation by the Ubiquitin-Proteasome System.Bioinformatics analysis identifies several intrinsically disordered human E3 ubiquitin-protein ligases.To be disordered or not to be disordered: is that still a question for proteins in the cell?Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism.A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis.Global ubiquitination analysis reveals extensive modification and proteasomal degradation of cowpox virus proteins, but preservation of viral cores.Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer.Proteolytic degradation of regulator of G protein signaling 2 facilitates temporal regulation of Gq/11 signaling and vascular contraction.Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution.Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins.Evolutionary Divergent Suppressor Mutations in Conformational Diseases
P2860
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P2860
Tripartite degrons confer diversity and specificity on regulated protein degradation in the ubiquitin-proteasome system.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
@zh-hant
name
Tripartite degrons confer dive ...... e ubiquitin-proteasome system.
@en
Tripartite degrons confer dive ...... e ubiquitin-proteasome system.
@nl
type
label
Tripartite degrons confer dive ...... e ubiquitin-proteasome system.
@en
Tripartite degrons confer dive ...... e ubiquitin-proteasome system.
@nl
prefLabel
Tripartite degrons confer dive ...... e ubiquitin-proteasome system.
@en
Tripartite degrons confer dive ...... e ubiquitin-proteasome system.
@nl
P2093
P2860
P356
P1476
Tripartite degrons confer dive ...... he ubiquitin-proteasome system
@en
P2093
Mainak Guharoy
Mohamed Sallam
Peter Tompa
P2860
P2888
P356
10.1038/NCOMMS10239
P407
P577
2016-01-06T00:00:00Z