Nicotine normalizes intracellular subunit stoichiometry of nicotinic receptors carrying mutations linked to autosomal dominant nocturnal frontal lobe epilepsy.
about
Pharmacological chaperoning: a primer on mechanism and pharmacologyInside-out neuropharmacology of nicotinic drugsInsights into the neurobiology of the nicotinic cholinergic system and nicotine addiction from mice expressing nicotinic receptors harboring gain-of-function mutationsAltered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the β2 nicotinic receptor.GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRETGABA acts as a ligand chaperone in the early secretory pathway to promote cell surface expression of GABAA receptorsNicotine up-regulates alpha4beta2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoningMenthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward.RIC-3 differentially modulates α4β2 and α7 nicotinic receptor assembly, expression, and nicotine-induced receptor upregulationNicotinic receptor subtype-selective circuit patterns in the subthalamic nucleus.Characterizing functional α6β2 nicotinic acetylcholine receptors in vitro: mutant β2 subunits improve membrane expression, and fluorescent proteins reveal responsive cells.Trafficking of alpha4* nicotinic receptors revealed by superecliptic phluorin: effects of a beta4 amyotrophic lateral sclerosis-associated mutation and chronic exposure to nicotineNeural systems governed by nicotinic acetylcholine receptors: emerging hypotheses.Pharmacological chaperoning of nicotinic acetylcholine receptors reduces the endoplasmic reticulum stress response.Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity α4β2, and Increases α5α4β2, Nicotinic Receptor Surface ExpressionFörster resonance energy transfer (FRET) correlates of altered subunit stoichiometry in cys-loop receptors, exemplified by nicotinic α4β2.Differential α4(+)/(-)β2 Agonist-binding Site Contributions to α4β2 Nicotinic Acetylcholine Receptor Function within and between Isoforms.The 5-HT3AB receptor shows an A3B2 stoichiometry at the plasma membrane.Allosteric modulators of α4β2 nicotinic acetylcholine receptors: a new direction for antidepressant drug discovery.Additional acetylcholine (ACh) binding site at alpha4/alpha4 interface of (alpha4beta2)2alpha4 nicotinic receptor influences agonist sensitivity.The role of nicotinic acetylcholine receptors in autosomal dominant nocturnal frontal lobe epilepsy.Ion Channel Genes and Epilepsy: Functional Alteration, Pathogenic Potential, and Mechanism of Epilepsy.Insights into nicotinic receptor signaling in nicotine addiction: Implications for prevention and treatment.Distinctive effects of nicotinic receptor intracellular-loop mutations associated with nocturnal frontal lobe epilepsy.Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales.Structural principles of distinct assemblies of the human α4β2 nicotinic receptor.
P2860
Q27001695-DC1CF8B6-A9B4-44CD-9AFB-8BDF06320589Q27010347-6A854DDA-627C-42AC-B64D-1CCEC1837821Q30448803-7D68321F-0CFE-4000-B7CD-9AFF39E80563Q30497231-B13A772B-93D7-46E1-82C0-835E8E921913Q33590316-4EEB0458-9D39-4EC9-A8C3-DA5D80CC94AEQ34140020-67DAC5DD-B609-4441-B442-D8D1B547AD18Q34439566-F6153F0F-D991-4CC6-8E15-658F92A6A729Q34517579-CA6045D8-B9D4-4A04-B451-94FCFF7A9DDBQ34668336-788BFEE0-B07C-4CDC-9951-F2ED4D8D72D5Q35142884-07CFA027-CE5D-4333-AB60-91EDA6F13743Q35182023-3381A02C-E796-4DFD-8CC8-7BD148C56035Q35213235-4559EAD8-6E34-4F3E-8E95-0882393371C9Q35566709-EFB03517-2AD3-4014-A8F0-B64A88EFAFF3Q35996739-F7E6ACD2-A8A7-48B9-BF8C-F1355C58B5CAQ36059982-99D980CD-9345-4690-9909-02136EC5F302Q36202419-D3F29A47-417D-444E-BB65-C5C2F6D51B1EQ36518363-D9334716-5044-4511-97D3-15EF4FC0CD84Q37117442-766619B6-13EB-4A5D-9D4A-AECA3144118EQ38063303-98A0FFB5-298C-4DAA-9951-C9AF95B0D614Q38264151-9069E799-F9EF-4E0D-A87F-337F4C5BEA18Q38365379-F269F1C2-B325-496B-AC46-5435A3728C17Q38795017-ECAB8867-7234-4620-94AC-046AB11F9672Q40111690-AC22B1CF-95F8-47A6-B081-5BA94DE75625Q41378172-9F278891-3894-4EEA-8771-9368F0F232C9Q42728501-67848137-899F-4249-BB44-6867D44F085EQ52330911-B28AC5A0-BE3F-49EC-8841-B8E1D629D229Q52714468-4566E6C2-0D79-4633-BB51-EE466715A187
P2860
Nicotine normalizes intracellular subunit stoichiometry of nicotinic receptors carrying mutations linked to autosomal dominant nocturnal frontal lobe epilepsy.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Nicotine normalizes intracellu ...... cturnal frontal lobe epilepsy.
@en
Nicotine normalizes intracellu ...... cturnal frontal lobe epilepsy.
@nl
type
label
Nicotine normalizes intracellu ...... cturnal frontal lobe epilepsy.
@en
Nicotine normalizes intracellu ...... cturnal frontal lobe epilepsy.
@nl
prefLabel
Nicotine normalizes intracellu ...... cturnal frontal lobe epilepsy.
@en
Nicotine normalizes intracellu ...... cturnal frontal lobe epilepsy.
@nl
P2860
P356
P1476
Nicotine normalizes intracellu ...... cturnal frontal lobe epilepsy.
@en
P2093
Bruce N Cohen
Henry A Lester
P2860
P304
P356
10.1124/MOL.108.054494
P577
2009-02-23T00:00:00Z