Signaling by TGF-beta Receptor Complex in Cancer - Wikidata - thesis-toulmin - TriplyDB

Signaling by TGF-beta Receptor Complex in Cancer

Signaling by TGF-beta Receptor Complex in Cancer

http://www.wikidata.org/entity/Q45314392

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Loss of Function of SMAD4 in Cancer Loss of Function of SMAD2/3 in Cancer Loss of Function of TGFBR2 in Cancer Loss of Function of TGFBR1 in Cancer

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Diseases of signal transduction

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Signaling by TGF-beta Receptor Complex in Cancer

http://www.wikidata.org/entity/Q45314392

description

An instance of the biological ...... plex in Cancer in Homo sapiens

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name

Signaling by TGF-beta Receptor Complex in Cancer

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type

label

Signaling by TGF-beta Receptor Complex in Cancer

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prefLabel

Signaling by TGF-beta Receptor Complex in Cancer

@en

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p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation

A structural basis for mutational inactivation of the tumour suppressor Smad4

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia.

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

Regulation of EMT by TGFβ in cancer.

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reactome:R-HSA-3304351

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biological pathway

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Diseases of signal transduction

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R-HSA-3304351

http://www.w3.org/2001/XMLSchema#string

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Loss of Function of SMAD4 in Cancer

Loss of Function of SMAD2/3 in Cancer

Loss of Function of TGFBR2 in Cancer

Loss of Function of TGFBR1 in Cancer

P703