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Proteoglycan metabolism, cell death and Kashin-Beck diseaseChondroitin sulfate sulfation motifs as putative biomarkers for isolation of articular cartilage progenitor cellsThe role of human HtrA1 in arthritic diseaseImmunodetection and partial cDNA sequence of the proteoglycan, superficial zone protein, synthesized by cells lining synovial joints.Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation.Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon.Catabolism of aggrecan, decorin and biglycan in tendon.Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism.An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients.Differential expression of the keratan sulphate proteoglycan, keratocan, during chick corneal embryogenesis.Increased expression of chondroitin sulphate proteoglycans in rat hepatocellular carcinoma tissues.Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.Matrix morphogenesis in cornea is mediated by the modification of keratan sulfate by GlcNAc 6-O-sulfotransferase.Measurement of aggrecanase-generated interglobular domain catabolites in the medium and extracts of cartilage explants using Western blot analysis.The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritisPromotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect.Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissuesThe role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis.Glucosamine Hydrochloride but Not Chondroitin Sulfate Prevents Cartilage Degradation and Inflammation Induced by Interleukin-1α in Bovine Cartilage Explants.Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development.TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors.Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing.ADAMTS-4_v1 is a splice variant of ADAMTS-4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain.Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration.Dietary fatty acids and arthritis.Differential relative sulfation of Keratan sulfate glycosaminoglycan in the chick cornea during embryonic development.Histopathology of chondronecrosis development in knee articular cartilage in a rat model of Kashin-Beck disease using T-2 toxin and selenium deficiency conditions.Antibodies and immunohistochemistry in extracellular matrix research.Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage.The effect of beta-xylosides on the chondrogenic differentiation of mesenchymal stem cells.Modification of palm oil for anti-inflammatory nutraceutical properties.Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis.Phosphate prodrugs derived from N-acetylglucosamine have enhanced chondroprotective activity in explant cultures and represent a new lead in antiosteoarthritis drug discovery.Immunochemical localization of keratan sulfate proteoglycans in cornea, sclera, and limbus using a keratanase-generated neoepitope monoclonal antibody.Articular cartilage metabolism in patients with Kashin-Beck Disease: an endemic osteoarthropathy in China.Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system.Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase.Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes.
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P50
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Clare E. Hughes
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Clare E. Hughes
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Clare E. Hughes
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Clare E. Hughes
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Clare E. Hughes
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Clare E. Hughes
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Clare E. Hughes
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Clare E. Hughes
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Clare E. Hughes
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Clare E. Hughes
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Clare E. Hughes
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Clare E. Hughes
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Clare E. Hughes
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Clare E. Hughes
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Clare E. Hughes
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Clare E. Hughes
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Clare E. Hughes
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Clare E. Hughes
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P106
P1153
7401856527
P21
P31
P496
0000-0003-4726-5877