A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin.
about
Polycomb group targeting through different binding partners of RING1B C-terminal domainMonoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligaseSeveral distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locusUbiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressorRYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3BMI1-mediated histone ubiquitylation promotes DNA double-strand break repairTranscriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activityBMI1-RING1B is an autoinhibited RING E3 ubiquitin ligaseA novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1Mitogen-activated protein kinase signaling mediates phosphorylation of polycomb ortholog Cbx7.Histone H2A monoubiquitination and Polycomb repression: the missing pieces of the puzzle.Genome-wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes.KAP1 represses differentiation-inducible genes in embryonic stem cells through cooperative binding with PRC1 and derepresses pluripotency-associated genesA chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage.REST interacts with Cbx proteins and regulates polycomb repressive complex 1 occupancy at RE1 elementsPRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.Role of polycomb group protein cbx2/m33 in meiosis onset and maintenance of chromosome stability in the Mammalian germline.Intronic RNAs mediate EZH2 regulation of epigenetic targets.Cbx2 stably associates with mitotic chromosomes via a PRC2- or PRC1-independent mechanism and is needed for recruiting PRC1 complex to mitotic chromosomesPolycomb group complexes--many combinations, many functions.Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells.Chromatin regulatory mechanisms in pluripotency.Combinatorial interactions are required for the efficient recruitment of pho repressive complex (PhoRC) to polycomb response elements.Genes and Conditions Controlling Mammalian Pre- and Post-implantation Embryo Development.Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.A core subunit of Polycomb repressive complex 1 is broadly conserved in function but not primary sequence.Independent Mechanisms Target SMCHD1 to Trimethylated Histone H3 Lysine 9-Modified Chromatin and the Inactive X Chromosome.Distinct Cellular Assembly Stoichiometry of Polycomb Complexes on Chromatin Revealed by Single-molecule Chromatin Immunoprecipitation Imaging.Epigenetics of pluripotent cells.RNF2/Ring1b negatively regulates p53 expression in selective cancer cell types to promote tumor development.Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locusLive-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin.RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.Talking to chromatin: post-translational modulation of polycomb group function.Polycomb group protein gene silencing, non-coding RNA, stem cells, and cancer.PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes.Gene silencing by the Polycomb group proteins and associations with cancer.The time of timing: how Polycomb proteins regulate neurogenesis.Combinatorial assembly and function of chromatin regulatory complexes.Factor mediated gene priming in pluripotent stem cells sets the stage for lineage specification.
P2860
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P2860
A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
A phosphorylated form of Mel-1 ...... ubiquitin ligase to chromatin.
@en
A phosphorylated form of Mel-1 ...... ubiquitin ligase to chromatin.
@nl
type
label
A phosphorylated form of Mel-1 ...... ubiquitin ligase to chromatin.
@en
A phosphorylated form of Mel-1 ...... ubiquitin ligase to chromatin.
@nl
prefLabel
A phosphorylated form of Mel-1 ...... ubiquitin ligase to chromatin.
@en
A phosphorylated form of Mel-1 ...... ubiquitin ligase to chromatin.
@nl
P2093
P1433
P1476
A phosphorylated form of Mel-1 ...... ubiquitin ligase to chromatin.
@en
P2093
Donna L Mallery
Gordon Peters
Kevin Hiom
Mitsuhiro Endoh
Neil Brockdorff
Nick Morrice
Sarah Elderkin
P304
P356
10.1016/J.MOLCEL.2007.08.009
P577
2007-10-01T00:00:00Z