Differential peptide dynamics is linked to major histocompatibility complex polymorphism.
about
Epitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complexStructures of MART-126/27–35 Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell RecognitionT Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular FlexibilityLoss of recognition by cross-reactive T cells and its relation to a C-terminus-induced conformational reorientation of an HLA-B*2705-bound peptideStructure-based design of altered MHC class II-restricted peptide ligands with heterogeneous immunogenicityNew conformational state of NHERF1-CXCR2 signaling complex captured by crystal lattice trappingProline substitution independently enhances H-2D(b) complex stabilization and TCR recognition of melanoma-associated peptidesSelector function of MHC I molecules is determined by protein plasticityPeptide modulation of class I major histocompatibility complex protein molecular flexibility and the implications for immune recognition.Two HLA-B14 subtypes (B*1402 and B*1403) differentially associated with ankylosing spondylitis differ substantially in peptide specificity but have limited peptide and T-cell epitope sharing with HLA-B27.Predicting important residues and interaction pathways in proteins using Gaussian Network Model: binding and stability of HLA proteins.Interaction pattern of Arg 62 in the A-pocket of differentially disease-associated HLA-B27 subtypes suggests distinct TCR binding modes.Influence of dominant HIV-1 epitopes on HLA-A3/peptide complex formation.MODPROPEP: a program for knowledge-based modeling of protein-peptide complexesCumulative autoimmunity: T cell clones recognizing several self-epitopes exhibit enhanced pathogenicityThe Dynamics of the Human Leukocyte Antigen Head Domain Modulates Its Recognition by the T-Cell Receptor.A computational docking study on the pH dependence of peptide binding to HLA-B27 sub-types differentially associated with ankylosing spondylitis.Comparative molecular dynamics analysis of tapasin-dependent and -independent MHC class I alleles.T-cell epitope vaccine design by immunoinformatics.Thermodynamic basis for promiscuity and selectivity in protein-protein interactions: PDZ domains, a case study.Thermodynamics of T-cell receptor-peptide/MHC interactions: progress and opportunitiesConformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes.TCR scanning of peptide/MHC through complementary matching of receptor and ligand molecular flexibility.Structural and dynamic control of T-cell receptor specificity, cross-reactivity, and binding mechanism.Peptide and Peptide-Dependent Motions in MHC Proteins: Immunological Implications and Biophysical Underpinnings.Proofreading of Peptide-MHC Complexes through Dynamic Multivalent Interactions.Recent advances in Major Histocompatibility Complex (MHC) class I antigen presentation: Plastic MHC molecules and TAPBPR-mediated quality control.Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation.Conformational flexibility of the MHC class I alpha1-alpha2 domain in peptide bound and free states: a molecular dynamics simulation study.Conformational dimorphism of self-peptides and molecular mimicry in a disease-associated HLA-B27 subtype.Allele-dependent similarity between viral and self-peptide presentation by HLA-B27 subtypes.Single-molecule motions of MHC class II rely on bound peptides.Natural MHC class I polymorphism controls the pathway of peptide dissociation from HLA-B27 complexesFormation and reversible dissociation of coiled coil of peptide to the C-terminus of the HSV B5 protein: a time-resolved spectroscopic analysis.A general and efficient approach for NMR studies of peptide dynamics in class I MHC peptide binding grooves.Molecular determinants of major histocompatibility complex class I complex stability: shaping antigenic features through short and long range electrostatic interactions.NMR spectroscopy reveals unexpected structural variation at the protein-protein interface in MHC class I molecules.Influence of inflammation-related changes on conformational characteristics of HLA-B27 subtypes as detected by IR spectroscopy.The Role of Molecular Flexibility in Antigen Presentation and T Cell Receptor-Mediated SignalingAnalysis of key parameters for molecular dynamics of pMHC molecules
P2860
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P2860
Differential peptide dynamics is linked to major histocompatibility complex polymorphism.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Differential peptide dynamics is linked to major histocompatibility complex polymorphism.
@en
Differential peptide dynamics is linked to major histocompatibility complex polymorphism.
@nl
type
label
Differential peptide dynamics is linked to major histocompatibility complex polymorphism.
@en
Differential peptide dynamics is linked to major histocompatibility complex polymorphism.
@nl
prefLabel
Differential peptide dynamics is linked to major histocompatibility complex polymorphism.
@en
Differential peptide dynamics is linked to major histocompatibility complex polymorphism.
@nl
P2093
P2860
P50
P356
P1476
Differential peptide dynamics is linked to major histocompatibility complex polymorphism.
@en
P2093
Helmut Grubmüller
Thomas Pöhlmann
Ulrike Alexiev
P2860
P304
28197-28201
P356
10.1074/JBC.C400128200
P407
P577
2004-04-14T00:00:00Z