P1346
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratioLRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosisPresenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutationsLRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanismPINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402Parkin interacts with Ambra1 to induce mitophagyLipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in miceLoss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer diseaseNear-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 modelThe yeast complex I equivalent NADH dehydrogenase rescues pink1 mutantsPresenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesisEndoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-proteinOPA1 controls apoptotic cristae remodeling independently from mitochondrial fusionCoordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivationPresenilin-1 maintains a nine-transmembrane topology throughout the secretory pathwayBACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's diseasePresenilin clinical mutations can affect gamma-secretase activity by different mechanismsMitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodelingRegulation of amyloid precursor protein processing by serotonin signalingGene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse modelsNotch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somitesPresenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathwayCoordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneityPINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncouplingCardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiencyPhosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.Alteration of the microRNA network during the progression of Alzheimer's disease.beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase.Tau association with synaptic vesicles causes presynaptic dysfunction.Differential contribution of the three Aph1 genes to gamma-secretase activity in vivoCell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling.Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.The secretases: enzymes with therapeutic potential in Alzheimer disease.Role of presenilins in neuronal calcium homeostasisA physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortexProteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Prion protein in Alzheimer's pathogenesis: a hot and controversial issue.A cell biological perspective on Alzheimer's disease.APLP2 regulates neuronal stem cell differentiation during cortical development.
P50
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P50
description
moleculair bioloog
@nl
molecular biologist, professor
@en
molekylærbiolog
@da
name
Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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type
label
Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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prefLabel
Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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Bart De Strooper
@en
Bart De Strooper
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Bart De Strooper
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Bart De Strooper
@fr
Bart De Strooper
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Bart De Strooper
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Bart De Strooper
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P106
P166
P214
P244
P269
P1153
7006241978
P1412
P166
P21
P213
0000 0004 3486 1028
P214
P2381
P244
nb2010001246
P269
P27
P31
P3237
P496
0000-0001-5455-5819
P5463
De_Strooper_Bart
P569
1950-01-01T00:00:00Z