Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome.
about
Chansporter complexes in cell signaling.Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic CardiotoxicityCalmodulin confers calcium sensitivity to the stability of the distal intracellular assembly domain of Kv7.2 channels.Ca(2+)-Calmodulin and PIP2 interactions at the proximal C-terminus of Kv7 channels.Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking.PIP2 mediates functional coupling and pharmacology of neuronal KCNQ channels.Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis.Exploiting ion channel structure to assess rare variant pathogenicity.KCNE1 and KCNE3 modulate KCNQ1 channels by affecting different gating transitions.Never at rest: insights into the conformational dynamics of ion channels from cryo-electron microscopy.Inactivation gating of Kv7.1 channels does not involve concerted cooperative subunit interactions.Effects of protein-protein interactions and ligand binding on the ion permeation in KCNQ1 potassium channel.A Calmodulin C-Lobe Ca2+-Dependent Switch Governs Kv7 Channel Function.Microbiology catches the cryo-EM bug.Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1.How to Connect Cardiac Excitation to the Atomic Interactions of Ion Channels.Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations.Direct neurotransmitter activation of voltage-gated potassium channels.The Role of KCNQ1 Mutations and Maternal Beta Blocker Use During Pregnancy in the Growth of Children With Long QT Syndrome.Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1.KCNE1 tunes the sensitivity of K7.1 to polyunsaturated fatty acids by moving turret residues close to the binding siteAncient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocketLack of correlation between surface expression and currents in epileptogenic AB-calmodulin binding domain Kv7.2 potassium channel mutantsMechanisms Underlying the Dual Effect of Polyunsaturated Fatty Acid Analogs on Kv7.1Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation
P2860
Q39441418-CAD963AC-116C-4433-9C5E-9DCB0AC17EC0Q41684522-A3545D04-D0D1-4478-8C85-B03C93EC0524Q42677580-78526841-EA99-43BC-869F-934A6D77C92AQ42694899-5CBFFEC4-9DFC-482A-AD9F-B82C0B3FE001Q42705191-1A83E61A-A371-4FB6-8079-DF6A695414ABQ46335684-6C06BD87-0A3A-4608-A0FA-DA9A602F15CEQ47146443-956FA3E5-403D-4D8A-B1E5-6659D596E539Q47554054-D1D2FBB7-55A5-4F13-9952-55754D750A7FQ47928241-803A5F3F-73B0-49AA-9699-9ED4948115E8Q48152291-E0259328-F11D-421A-850A-C78BB757FE95Q49942779-816EE3C4-19E8-4916-AE9F-275732DB3E92Q50000622-8A0FDEBD-D0A2-4EE7-91BE-5E51F993DB41Q50074758-A6366C8B-7F67-40D9-BA6A-AB46E7D364B5Q52431569-C0025E80-8B64-42CA-B767-D95895304420Q52641805-C22C966E-7685-45E9-A766-0B42D83DB6DAQ52699573-42B0254F-A05C-4A94-879D-991197DF38DCQ55015504-FBC0BC52-0870-4EC1-ADE3-8CFA346D6F7CQ55041760-020F565B-44D1-48D1-8F1D-BC633D6386FCQ55314339-04C8A571-144B-4038-84B9-FA7BFE0766D1Q55499894-EB2D67CA-73FF-4A8D-874D-DAE5A64D166FQ56534190-D23B6645-14F2-4E58-9ED3-116AF7656613Q57921983-A89BF87B-544F-4B71-99BA-0F3324588D01Q58694694-0261209F-B52D-49B4-9B1F-DBD4E5E67D85Q58749124-AD78D922-D85A-430E-AD44-8935696840D6Q59132642-775862B5-D77A-4C26-8475-704E4213D794
P2860
Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome.
description
2017 nî lūn-bûn
@nan
2017年の論文
@ja
2017年学术文章
@wuu
2017年学术文章
@zh
2017年学术文章
@zh-cn
2017年学术文章
@zh-hans
2017年学术文章
@zh-my
2017年学术文章
@zh-sg
2017年學術文章
@yue
2017年學術文章
@zh-hant
name
Cryo-EM Structure of a KCNQ1/C ...... o Congenital Long QT Syndrome.
@en
Cryo-EM Structure of a KCNQ1/C ...... o Congenital Long QT Syndrome.
@nl
type
label
Cryo-EM Structure of a KCNQ1/C ...... o Congenital Long QT Syndrome.
@en
Cryo-EM Structure of a KCNQ1/C ...... o Congenital Long QT Syndrome.
@nl
prefLabel
Cryo-EM Structure of a KCNQ1/C ...... o Congenital Long QT Syndrome.
@en
Cryo-EM Structure of a KCNQ1/C ...... o Congenital Long QT Syndrome.
@nl
P2860
P1433
P1476
Cryo-EM Structure of a KCNQ1/C ...... o Congenital Long QT Syndrome.
@en
P2093
P2860
P304
1042-1050.e9
P356
10.1016/J.CELL.2017.05.019
P407
P577
2017-06-01T00:00:00Z