about
Synthetic strategy and antiviral evaluation of diamide containing heterocycles targeting dengue and yellow fever virusCrystal structure of double helical hexitol nucleic acidsCleavage of DNA without loss of genetic information by incorporation of a disaccharide nucleosideSelective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness.Characterization and sequence confirmation of unnatural amino acid containing peptide libraries using electrospray ionization mass spectrometry.New dsDNA binding unnatural oligopeptides with pyrimidine selectivity.Comparison of library screening techniques used in the development of dsDNA ligands.MccE provides resistance to protein synthesis inhibitor microcin C by acetylating the processed form of the antibiotic.The mechanism of microcin C resistance provided by the MccF peptidaseAn acyclic 5-nitroindazole nucleoside analogue as ambiguous nucleosideN-alkylated aminoacyl sulfamoyladenosines as potential inhibitors of aminoacylation reactions and microcin C analogues containing D-amino acids.Hybridization specificity, enzymatic activity and biological (Ha-ras) activity of oligonucleotides containing 2,4-dideoxy-beta-D-erythro-hexopyranosyl nucleosidesIdentification of a peptide inhibitor against glycosomal phosphoglycerate kinase of Trypanosoma brucei by a synthetic peptide library approach.Synthesis of 1,5-anhydrohexitol building blocks for oligonucleotide synthesis.A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicityAminoacyl-tRNA synthetase inhibitors as potential antibiotics.Aminoacyl-tRNA synthetase inhibitors as antimicrobial agents: a patent review from 2006 till present.DNA duplexes with reactive dialdehyde groups as novel reagents for cross-linking to restriction- modification enzymes.Synthesis and stability of oligonucleotides containing acyclic achiral nucleoside analogues with two base moieties.Synthesis and base pairing properties of 1',5'-anhydro-L-hexitol nucleic acids (L-HNA).Affinity modification of EcoRII DNA methyltransferase by the dialdehyde-substituted DNA duplexes: mapping the enzyme region that interacts with DNA.Renaissance in Antibiotic Discovery: Some Novel Approaches for Finding Drugs to Treat Bad Bugs.Spectroscopic Investigation of the Formation and Disruption of Hydrogen Bonds in Pharmaceutical Semicrystalline Dispersions.Improved hybridisation potential of oligonucleotides comprising O-methylated anhydrohexitol nucleoside congenersSubstituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer's disease.Chemical incorporation of 1-methyladenosine into oligonucleotides.Synthesis and hybridization properties of inverse oligonucleotides.Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf.Inhibition of MDR1 gene expression by chimeric HNA antisense oligonucleotides.Crystallization and preliminary X-ray study of the D-altritol oligonucleotide GTGTACAC.An easy and fast method for the evaluation of Staphylococcus epidermidis type I signal peptidase inhibitors.Aminopurine and aminoquinazoline scaffolds for development of potential dengue virus inhibitors.Inhibition of human immunodeficiency virus type 1 transcription by N-aminoimidazole derivatives.In vitro accumulation and permeation of hypericin and lipophilic analogues in 2-D and 3-D cellular systems.Synthesis and evaluation of imidazole-4,5- and pyrazine-2,3-dicarboxamides targeting dengue and yellow fever virus.In search of Flavivirus inhibitors part 2: tritylated, diphenylmethylated and other alkylated nucleoside analogues.In search of flavivirus inhibitors: evaluation of different tritylated nucleoside analogues.3',5'Di-O-trityluridine inhibits in vitro flavivirus replication.Synthesis, in vitro cellular uptake and photo-induced antiproliferative effects of lipophilic hypericin acid derivatives.Replication of hexitol oligonucleotides as a prelude to the propagation of a third type of nucleic acid in vivo.
P50
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P50
description
hulumtues
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researcher
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հետազոտող
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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Arthur Van Aerschot
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P106
P1153
35403938800
P21
P31
P496
0000-0003-3528-8588