Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM.
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Cyclooxygenase-2 selective inhibition with NS-398 suppresses proliferation and invasiveness and delays liver metastasis in colorectal cancerInitiation of human colon cancer cell proliferation by trypsin acting at protease-activated receptor-2Precursor peptide progastrin(1-80) reduces apoptosis of intestinal epithelial cells and upregulates cytochrome c oxidase Vb levels and synthesis of ATPProgastrin Peptides Increase the Risk of Developing Colonic Tumors: Impact on Colonic Stem CellsGastrins, iron homeostasis and colorectal cancerDownregulation of the CCK-B receptor in pancreatic cancer cells blocks proliferation and promotes apoptosisP53 gene mutation increases progastrin dependent colonic proliferation and colon cancer formation in miceMouse models of gastric cancer.Inactivating cholecystokinin-2 receptor inhibits progastrin-dependent colonic crypt fission, proliferation, and colorectal cancer in mice.Functional cross-talk between beta-catenin and NFkappaB signaling pathways in colonic crypts of mice in response to progastrin.The production and role of gastrin-17 and gastrin-17-gly in gastrointestinal cancers.COX-2 selective inhibition reverses the trophic properties of gastrin in colorectal cancer.The structure of bioactive analogs of the N-terminal region of gastrin-17.Bioactivity of analogs of the N-terminal region of gastrin-17.Activation of NF-kappaB is required for mediating proliferative and antiapoptotic effects of progastrin on proximal colonic crypts of mice, in vivo.COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo.Progastrin1-80 stimulates growth of intestinal epithelial cells in vitro via high-affinity binding sites.
P2860
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P2860
Mice overexpressing progastrin are predisposed for developing aberrant colonic crypt foci in response to AOM.
description
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name
Mice overexpressing progastrin ...... crypt foci in response to AOM.
@en
Mice overexpressing progastrin ...... crypt foci in response to AOM.
@nl
type
label
Mice overexpressing progastrin ...... crypt foci in response to AOM.
@en
Mice overexpressing progastrin ...... crypt foci in response to AOM.
@nl
prefLabel
Mice overexpressing progastrin ...... crypt foci in response to AOM.
@en
Mice overexpressing progastrin ...... crypt foci in response to AOM.
@nl
P2093
P2860
P1476
Mice overexpressing progastrin ...... crypt foci in response to AOM.
@en
P2093
P2860
P304
P356
10.1152/AJPGI.2000.278.3.G390
P577
2000-03-01T00:00:00Z