The crystal structure of human CD1b with a bound bacterial glycolipid14-3-3 activation of DNA binding of p53 by enhancing its association into tetramersMechanistic differences in the transcriptional activation of p53 by 14-3-3 isoformsS100 proteins interact with the N-terminal domain of MDM2How and why to publish in PNASA peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutantsTwo sequence motifs from HIF-1alpha bind to the DNA-binding site of p53.Characterization of the native and fibrillar conformation of the human Nalpha-acetyltransferase ARD1Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53Quaternary structures of tumor suppressor p53 and a specific p53 DNA complexPFD: a database for the investigation of protein folding kinetics and stabilityLoss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish typeMimicking natural evolution in vitro: An N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activityCrystal structures of engrailed homeodomain mutants: implications for stability and dynamicsCrystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutationsThe helix turn helix motif as an ultrafast independently folding domain: The pathway of folding of Engrailed homeodomainSolution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like foldTargeted rescue of a destabilized mutant of p53 by an in silico screened drugStructure of human MDM4 N-terminal domain bound to a single-domain antibodySolution structure of the U11-48K CHHC zinc-finger domain that specifically binds the 5' splice site of U12-type intronsThe folding mechanism of BBL: Plasticity of transition-state structure observed within an ultrafast folding protein familyStabilising the DNA-binding domain of p53 by rational design of its hydrophobic coreStructural evolution of p53, p63, and p73: Implication for heterotetramer formationEngineering a two-helix bundle protein for folding studiesToward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutantA transient and low-populated protein-folding intermediate at atomic resolutionNonnative Interactions in the FF Domain Folding Pathway from an Atomic Resolution Structure of a Sparsely Populated Intermediate: An NMR Relaxation Dispersion StudyInteraction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 TetramerAcetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentrationSmall molecule induced reactivation of mutant p53 in cancer cellsHalogen-Enriched Fragment Libraries as Leads for Drug Rescue of Mutant p53Sequential unfolding of ankyrin repeats in tumor suppressor p16Phi value versus psi analysisProfile of Martin Karplus, Michael Levitt, and Arieh Warshel, 2013 nobel laureates in chemistryHarnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue DrugsBinding of natively unfolded HIF-1alpha ODD domain to p53Transition-state structure as a unifying basis in protein-folding mechanisms: contact order, chain topology, stability, and the extended nucleus mechanism.Directed evolution of new catalytic activity using the alpha/beta-barrel scaffold.Folding of circular and permuted chymotrypsin inhibitor 2: retention of the folding nucleus.Nonsequential unfolding of the alpha/beta barrel protein indole-3-glycerol-phosphate synthase.
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subject
description
British chemist
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British chemist
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British chemist
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Brits scheikundige
@nl
Suurbritannia keemik
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britischer Chemiker
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chimist britanic
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chimiste britannique
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kimist britanik
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químic britànic
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name
Alan Fersht
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Alan Fersht
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Alan Fersht
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Alan Fersht
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Alan Fersht
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Alan Fersht
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Alan Fersht
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Alan Fersht
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Alan Fersht
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Alan Fersht
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type
label
Alan Fersht
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Alan Fersht
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Alan Fersht
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Alan Fersht
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Alan Fersht
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Alan Fersht
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Alan Fersht
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Alan Fersht
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Alan Fersht
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Alan Fersht
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altLabel
Alan R. Fersht
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Alan Roy Fersht
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Fersht
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Sir Alan Fersht
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Alan Fersht
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Alan Fersht
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Alan Fersht
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Alan Fersht
@en
Alan Fersht
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Alan Fersht
@fr
Alan Fersht
@hu
Alan Fersht
@it
Alan Fersht
@nl
Alan Fersht
@pt