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Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sitesChlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT.Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporterQuinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum1H-NMR metabolite profiles of different strains of Plasmodium falciparum.Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT).Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs.A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT.Functional characteristics of the malaria parasite's "chloroquine resistance transporter": implications for chemotherapy.
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description
onderzoeker
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researcher
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ricercatore
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հետազոտող
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name
Robert L Summers
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Robert L Summers
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Robert L Summers
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Robert L Summers
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Robert L Summers
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type
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Robert L Summers
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Robert L Summers
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Robert L Summers
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Robert L Summers
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Robert L Summers
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prefLabel
Robert L Summers
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Robert L Summers
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Robert L Summers
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Robert L Summers
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Robert L Summers
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P21
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12146522470832392744
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P496
0000-0003-0840-1784