about
Matrix crosslinking forces tumor progression by enhancing integrin signalingTargeting ECM Disrupts Cancer ProgressionLysyl oxidase mediates hypoxic control of metastasisThe role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasisMulti-Channel Optical Coherence Elastography Using Relative and Absolute Shear-Wave Time of FlightRemodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer.Tissue section AFM: In situ ultrastructural imaging of native biomolecules.Correlation of Ultrasound Shear Wave Elastography with Pathological Analysis in a Xenografic Tumour ModelPre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer.Bid, a widely expressed proapoptotic protein of the Bcl-2 family, displays lipid transfer activity.Ionizing radiation induces tumor cell lysyl oxidase secretion.Structural ECM components in the premetastatic and metastatic niche.The pre-metastatic niche: is metastasis random?Identification of hypoxia-regulated proteins using MALDI-mass spectrometry imaging combined with quantitative proteomics.Pten Regulates Epithelial Cytodifferentiation during Prostate Development.Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasisContrasting effects of sunitinib within in vivo models of metastasis.Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesisHypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance.Three-dimensional context regulation of metastasis.The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.Tumor-secreted LOXL2 activates fibroblasts through FAK signaling.Network-based drugs and biomarkers.Dynamics of cancerous tissue correlates with invasiveness.LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling.STRIPAK components determine mode of cancer cell migration and metastasis.The rationale for targeting the LOX family in cancer.Lysyl oxidase in colorectal cancer.Hypoxia-mediated metastasis.The potential for targeting extracellular LOX proteins in human malignancy.Lysyl oxidase in cancer research.Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism.Fibrosis and Cancer: Partners in Crime or Opposing Forces?Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis.ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix.Pre-metastatic niches: organ-specific homes for metastases.AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival.Quantification of Lung Metastases from In Vivo Mouse Models.
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P50
description
hulumtuese
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onderzoeker
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researcher
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հետազոտող
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name
Janine T. Erler
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Janine T. Erler
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Janine T. Erler
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Janine T. Erler
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Janine T. Erler
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Janine T. Erler
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Janine T. Erler
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Janine T. Erler
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Janine T. Erler
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Janine T. Erler
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prefLabel
Janine T. Erler
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Janine T. Erler
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Janine T. Erler
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Janine T. Erler
@nl
Janine T. Erler
@sl
P106
P1153
8788908500
P21
P31
P496
0000-0001-8675-6527