about
Rational HIV Immunogen Design to Target Specific Germline B Cell ReceptorsCex1p is a novel cytoplasmic component of the Saccharomyces cerevisiae nuclear tRNA export machineryCex1p facilitates Rna1p-mediated dissociation of the Los1p-tRNA-Gsp1p-GTP export complex.Structural modeling identified the tRNA-binding domain of Utp8p, an essential nucleolar component of the nuclear tRNA export machinery of Saccharomyces cerevisiae.Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses.Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbsNutrient stress does not cause retrograde transport of cytoplasmic tRNA to the nucleus in evolutionarily diverse organisms.HIV antibodies. Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies.Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice.Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice.Structural basis for germline antibody recognition of HIV-1 immunogens.Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodiesDifferences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors.Diverse recombinant HIV-1 Envs fail to activate B cells expressing the germline B cell receptors of the broadly neutralizing anti-HIV-1 antibodies PG9 and 447-52D.Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections.Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope.An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus.Anti-HIV-1 B cell responses are dependent on B cell precursor frequency and antigen-binding affinity.Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 coreLive rubella vectors can express native HIV envelope glycoproteins targeted by broadly neutralizing antibodies and prime the immune response to an envelope protein boostDetection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypesAnti-idiotypic antibodies elicit anti-HIV-1-specific B cell responsesImmunization expands B cells specific to HIV-1 V3 glycan in mice and macaquesTargeting broadly neutralizing antibody precursors: a naïve approach to vaccine designHIV-specific humoral immune responses by CRISPR/Cas9-edited B cells
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description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Andrew McGuire
@ast
Andrew McGuire
@en
Andrew McGuire
@es
Andrew McGuire
@nl
type
label
Andrew McGuire
@ast
Andrew McGuire
@en
Andrew McGuire
@es
Andrew McGuire
@nl
prefLabel
Andrew McGuire
@ast
Andrew McGuire
@en
Andrew McGuire
@es
Andrew McGuire
@nl
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P31
P496
0000-0003-1841-6859