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The Molecular Receptive Ranges of Human TAS2R Bitter Taste ReceptorsIn vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringeninPolyacetylenes from sardinian Oenanthe fistulosa: a molecular clue to risus sardonicusReplacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responsesFunctionalization of β-Caryophyllene Generates Novel Polypharmacology in the Endocannabinoid SystemNoladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissuesN-Acylvanillamides: development of an expeditious synthesis and discovery of new acyl templates for powerful activation of the vanilloid receptor.Artarborol, a nor-caryophyllane sesquiterpene alcohol from Artemisia arborescens. stereostructure assignment through concurrence of NMR data and computational analysis.Arzanol, an anti-inflammatory and anti-HIV-1 phloroglucinol alpha-Pyrone from Helichrysum italicum ssp. microphyllum.Functional characterization of transient receptor potential channels in mouse urothelial cells.The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system.Falcarindiol allosterically modulates GABAergic currents in cultured rat hippocampal neurons.A cannabigerol quinone alleviates neuroinflammation in a chronic model of multiple sclerosis.Vanilloid receptor TRPV1 antagonists as the next generation of painkillers. Are we putting the cart before the horse?Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential.Recreational drug discovery: natural products as lead structures for the synthesis of smart drugs.In vitro antimalarial activity of hyperforin, a prenylated acylphloroglucinol. A structure-activity study.Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation.Euphorbium: modern research on its active principle, resiniferatoxin, revives an ancient medicine.Antibacterial cannabinoids from Cannabis sativa: a structure-activity study.Pharmacology of vanilloid transient receptor potential cation channels.The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin.Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1.Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia.Activation of TRPA1 on dural afferents: a potential mechanism of headache pain.Carbonyl Activation in Electrophilic Polyene Cyclizations: A Toolbox for the Design of Isoprenoid Libraries.Clinically useful vanilloid receptor TRPV1 antagonists: just around the corner (or too early to tell)?The role of natural products in the ligand deorphanization of TRP channels.Broccoli, PTEN deletion and prostate cancer: where is the link?Plant volatiles: production, function and pharmacology.The transient receptor potential channel TRPA1: from gene to pathophysiology.Spices: the savory and beneficial science of pungency.The génépi Artemisia species. Ethnopharmacology, cultivation, phytochemistry, and bioactivity.Poly-Electrophilic Sesquiterpene Lactones from Vernonia amygdalina: New Members and Differences in Their Mechanism of Thiol Trapping and in Bioactivity.Tasty and healthy TR(i)Ps. The human quest for culinary pungency.Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels.An NMR spectroscopic method to identify and classify thiol-trapping agents: revival of Michael acceptors for drug discovery?Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo.Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The side chain benzylic methylene.Anti-inflammatory and vascularprotective properties of 8-prenylapigenin.
P50
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Giovanni Appendino
@ast
Giovanni Appendino
@en
Giovanni Appendino
@es
Giovanni Appendino
@nl
type
label
Giovanni Appendino
@ast
Giovanni Appendino
@en
Giovanni Appendino
@es
Giovanni Appendino
@nl
prefLabel
Giovanni Appendino
@ast
Giovanni Appendino
@en
Giovanni Appendino
@es
Giovanni Appendino
@nl
P106
P21
P31
P496
0000-0002-4170-9919