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Replication-Competent Influenza A Viruses Expressing Reporter GenesReverse Genetics Approaches for the Development of Influenza VaccinesReplication-competent fluorescent-expressing influenza B virusInfluenza A virus attenuation by codon deoptimization of the NS gene for vaccine developmentInfluenza A and B virus intertypic reassortment through compatible viral packaging signals.Competitive detection of influenza neutralizing antibodies using a novel bivalent fluorescence-based microneutralization assay (BiFMA).Replication-competent influenza A viruses expressing a red fluorescent protein.Development of a mouse-adapted live attenuated influenza virus that permits in vivo analysis of enhancements to the safety of live attenuated influenza virus vaccine.Construction of a severe acute respiratory syndrome coronavirus infectious cDNA clone and a replicon to study coronavirus RNA synthesis.Development of live-attenuated arenavirus vaccines based on codon deoptimizationTransmissible gastroenteritis coronavirus RNA-dependent RNA polymerase and nonstructural proteins 2, 3, and 8 are incorporated into viral particles.Identification of a gamma interferon-activated inhibitor of translation-like RNA motif at the 3' end of the transmissible gastroenteritis coronavirus genome modulating innate immune responseDownregulating viral gene expression: codon usage bias manipulation for the generation of novel influenza A virus vaccines.Replication-Competent Influenza A and B Viruses Expressing a Fluorescent Dynamic Timer Protein for In Vitro and In Vivo Studies.Mutations Designed by Ensemble Defect to Misfold Conserved RNA Structures of Influenza A Segments 7 and 8 Affect Splicing and Attenuate Viral Replication in Cell CultureEngineering infectious cDNAs of coronavirus as bacterial artificial chromosomes.Mutagenesis of Coronavirus nsp14 Reveals Its Potential Role in Modulation of the Innate Immune Response.Rearrangement of Influenza Virus Spliced Segments for the Development of Live-Attenuated Vaccines.NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses.Development of live-attenuated arenavirus vaccines based on codon deoptimization of the viral glycoprotein.Development and applications of single-cycle infectious influenza A virus (sciIAV).A live-attenuated influenza vaccine for H3N2 canine influenza virus.Temperature-Sensitive Live-Attenuated Canine Influenza Virus H3N8 VaccineReverse Genetics of Influenza B Viruses.Immunogenic characterization and epitope mapping of transmissible gastroenteritis virus RNA dependent RNA polymerase.Host cell proteins interacting with the 3' end of TGEV coronavirus genome influence virus replication.Pandemic 2009 H1N1 Influenza Venus reporter virus reveals broad diversity of MHC class II-positive antigen-bearing cells following infection in vivo.The K186E Amino Acid Substitution in the Canine Influenza Virus H3N8 NS1 Protein Restores Its Ability To Inhibit Host Gene Expression.Oxygen-dependent changes in lung development do not affect epithelial infection with influenza A virus.A bivalent live-attenuated influenza vaccine for the control and prevention of H3N8 and H3N2 canine influenza viruses.Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N1 Viruses.Interplay of PA-X and NS1 Proteins in Replication and Pathogenesis of a Temperature-Sensitive 2009 Pandemic H1N1 Influenza A Virus.NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses.Canine influenza viruses with modified NS1 proteins for the development of live-attenuated vaccines.Influenza A Virus Studies in a Mouse Model of Infection.Antigenicity of the 2015-2016 seasonal H1N1 human influenza virus HA and NA proteins.Mammalian adaptation of an avian influenza A virus involves stepwise changes in NS1.Cigarette Smoke Dampens Anti-viral Signaling in Small Airway Epithelial Cells by Disrupting TLR3 Cleavage.Development of a novel equine influenza virus live-attenuated vaccine.Broad cross-reactive IgG responses elicited by adjuvanted vaccination with recombinant influenza hemagglutinin (rHA) in ferrets and mice.
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հետազոտող
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Aitor Nogales
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P106
P21
P31
P496
0000-0002-2424-7900