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Transmission of a 2009 H1N1 pandemic influenza virus occurs before fever is detected, in the ferret modelFurther studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signallingHepatitis C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity: mutagenic analysis of residues within the SH3 domain that contribute to the interactionA Conserved Proline between Domains II and III of Hepatitis C Virus NS5A Influences both RNA Replication and Virus AssemblyMutations in haemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibilityThe short stalk length of highly pathogenic avian influenza H5N1 virus neuraminidase limits transmission of pandemic H1N1 virus in ferretsEarly apoptosis of porcine alveolar macrophages limits avian influenza virus replication and pro-inflammatory dysregulation.Mutations in H5N1 influenza virus hemagglutinin that confer binding to human tracheal airway epithelium.Aerosol Delivery of a Candidate Universal Influenza Vaccine Reduces Viral Load in Pigs Challenged with Pandemic H1N1 Virus.Receptor binding profiles of avian influenza virus hemagglutinin subtypes on human cells as a predictor of pandemic potential.Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusionImmune Escape Variants of H9N2 Influenza Viruses Containing Deletions at the Hemagglutinin Receptor Binding Site Retain Fitness In Vivo and Display Enhanced Zoonotic CharacteristicsA single amino acid in the HA of pH1N1 2009 influenza virus affects cell tropism in human airway epithelium, but not transmission in ferrets.An influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated in vivo.Antigenic mapping of an H9N2 avian influenza virus reveals two discrete antigenic sites and a novel mechanism of immune escape.Lack of transmission of a human influenza virus with avian receptor specificity between ferrets is not due to decreased virus shedding but rather a lower infectivity in vivo.Adjuvant-free immunization with hemagglutinin-Fc fusion proteins as an approach to influenza vaccines.Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice.Animal Models in Influenza ResearchAssociation of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic PotentialSpecies specific differences in use of ANP32 proteins by influenza A virusThe cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Holly Shelton
@ast
Holly Shelton
@en
Holly Shelton
@es
Holly Shelton
@nl
type
label
Holly Shelton
@ast
Holly Shelton
@en
Holly Shelton
@es
Holly Shelton
@nl
prefLabel
Holly Shelton
@ast
Holly Shelton
@en
Holly Shelton
@es
Holly Shelton
@nl
P108
P106
P1153
8243087700
P31
P496
0000-0002-5776-0735