about
Machine-Learning-Assisted Approach for Discovering Novel Inhibitors Targeting Bromodomain-Containing Protein 4.Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferationNatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expressionDevelopment of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation.Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues.Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization.Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1.Identification of Selective, Cell Active Inhibitors of Protein Arginine Methyltransferase 5 through Structure-Based Virtual Screening and Biological Assays.Design, synthesis and biological evaluation of benzo[cd]indol-2(1H)-ones derivatives as BRD4 inhibitors.Identification of recurrent USP48 and BRAF mutations in Cushing's diseaseLead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitorsDiscovery of 8-Methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one Derivatives as Highly Potent and Selective Bromodomain and Extra-Terminal (BET) Bromodomain InhibitorsDevelopment and Characterization of a Fluorescent Probe for GLS1 and the Application for High-Throughput Screening of Allosteric InhibitorsDiscovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in VivoDiscovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluationDiscovery of novel trimethoxy-ring BRD4 bromodomain inhibitors: AlphaScreen assay, crystallography and cell-based assayThe identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screeningDesign, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive BacteriaLicochalcone A suppresses the proliferation of sarcoma HT-1080 cells, as a selective R132C mutant IDH1 inhibitorDiscovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacyDiscovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteinsThymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine
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P50
description
onderzoeker
@nl
researcher ORCID: 0000-0003-3864-8382
@en
name
Cheng Luo
@ast
Cheng Luo
@en
Cheng Luo
@es
Cheng Luo
@nl
type
label
Cheng Luo
@ast
Cheng Luo
@en
Cheng Luo
@es
Cheng Luo
@nl
prefLabel
Cheng Luo
@ast
Cheng Luo
@en
Cheng Luo
@es
Cheng Luo
@nl
P106
P31
P496
0000-0003-3864-8382