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How insulin engages its primary binding site on the insulin receptorStructural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonistsStructure of the haemagglutinin-neuraminidase from human parainfluenza virus type IIIA designed ankyrin repeat protein evolved to picomolar affinity to Her2A Molecular Mechanism for Bacterial Susceptibility to ZincProtective hinge in insulin opens to enable its receptor engagementStructural Congruency of Ligand Binding to the Insulin and Insulin/Type 1 Insulin-like Growth Factor Hybrid ReceptorsA minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulinAromatic anchor at an invariant hormone-receptor interface: function of insulin residue B24 with application to protein design.Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.The X-ray structure of a hemipteran ecdysone receptor ligand-binding domain: comparison with a lepidopteran ecdysone receptor ligand-binding domain and implications for insecticide design.α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase.The insulin receptor changes conformation in unforeseen ways on ligand binding: sharpening the picture of insulin receptor activation.Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change.A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor alpha-chain C-terminal peptide and the site 1 insulin mimetic peptides.Insulin in motion: The A6-A11 disulfide bond allosterically modulates structural transitions required for insulin activity.Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY.How ligand binds to the type 1 insulin-like growth factor receptor.Structure and Function of Ecdysone Receptors—Interactions with Ecdysteroids and Synthetic AgonistsA structurally minimized yet fully active insulin based on cone-snail venom insulin principles
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Michael C Lawrence
@ast
Michael C Lawrence
@en
Michael C Lawrence
@es
Michael C Lawrence
@nl
type
label
Michael C Lawrence
@ast
Michael C Lawrence
@en
Michael C Lawrence
@es
Michael C Lawrence
@nl
prefLabel
Michael C Lawrence
@ast
Michael C Lawrence
@en
Michael C Lawrence
@es
Michael C Lawrence
@nl
P106
P21
P31
P496
0000-0003-1999-0801