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The Novel Functions of the PLC/PKC/PKD Signaling Axis in G Protein-Coupled Receptor-Mediated Chemotaxis of NeutrophilsKey role of local regulation in chemosensing revealed by a new molecular interaction-based modeling method.Attenuation of phospholipid signaling provides a novel mechanism for the action of valproic acid.Tumor suppressor function of Syk in human MCF10A in vitro and normal mouse mammary epithelium in vivo.A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis.Imaging G-protein coupled receptor (GPCR)-mediated signaling events that control chemotaxis of Dictyostelium discoideum.Involvement of LIM kinase 1 in actin polarization in human CD4 T cells.HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cellsGenistein interferes with SDF-1- and HIV-mediated actin dynamics and inhibits HIV infection of resting CD4 T cells.ELMO1 Directly Interacts with Gβγ Subunit to Transduce GPCR Signaling to Rac1 Activation in Chemotaxis.Chemotaxis, chemokine receptors and human disease.How human leukocytes track down and destroy pathogens: lessons learned from the model organism Dictyostelium discoideum.ELMO proteins transduce G protein-coupled receptor signal to control reorganization of actin cytoskeleton in chemotaxis of eukaryotic cells.Monitoring dynamic GPCR signaling events using fluorescence microscopy, FRET imaging, and single-molecule imaging.GPCR-controlled membrane recruitment of negative regulator C2GAP1 locally inhibits Ras signaling for adaptation and long-range chemotaxis.Odd mating-type substances may work as precursor molecules of even mating-type substances in Paramecium caudatumUsing quantitative fluorescence microscopy and FRET imaging to measure spatiotemporal signaling events in single living cellsThe neuroprotective agent, valproic acid, regulates the mitogen-activated protein kinase pathway through modulation of protein kinase A signalling in Dictyostelium discoideumHIV gp120 is an aberrant chemoattractant for blood resting CD4 T cellsFilling GAPs in G protein- coupled receptor (GPCR)-mediated Ras adaptation and chemotaxis
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description
researcher ORCID ID = 0000-0002-3863-9593
@en
wetenschapper
@nl
name
Xuehua Xu
@ast
Xuehua Xu
@en
Xuehua Xu
@nl
type
label
Xuehua Xu
@ast
Xuehua Xu
@en
Xuehua Xu
@nl
prefLabel
Xuehua Xu
@ast
Xuehua Xu
@en
Xuehua Xu
@nl
P106
P31
P496
0000-0002-3863-9593