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IRF3-P:IRF7-P [nucleoplasm]IRF3;IRF7p-4S;T404-IRF3;p-S477;S479-IRF7p-T;4S-IRF3:p-T;4S-IRF3p-T;4S-IRF3:p-T;4S-IRF3 [nucleoplasm]IRF3-P:IRF7-Pp-IRF3:p-IRF3ISGylated IRF3dsDNA:ZBP1:pS-172-TBK:IRF3STING:TBK1:IRF3STING:p-S172-TBK1:IRF3STING:p-S172;K48polyUb-TBK1:IRF3IRF 1-9Recruitment of IRF3 to activated ZBP1:TBK1STING recruits TBK1 and IRF3ISGylation of IRF3
P527
P688
Activation of STAT6 by STING is critical for antiviral innate immunityRegulation of immunity and oncogenesis by the IRF transcription factor familyHepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunityDistinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophagesInvolvement of TIRAP/MAL in signaling for the activation of interferon regulatory factor 3 by lipopolysaccharideInteraction between the HCV NS3 protein and the host TBK1 protein leads to inhibition of cellular antiviral responsesType I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factorsReconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunityZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responsesIdentification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genesInhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virusInfluenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-IThe adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activationMAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune responseISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral responseThe transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune systemA small domain of CBP/p300 binds diverse proteins: solution structure and functional studiesStructure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancerStructural basis for suppression of a host antiviral response by influenza A virusStructural Insights into the Functions of TBK1 in Innate Antimicrobial ImmunityPhosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activationVirus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivoSTING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathwayInducible interleukin 32 (IL-32) exerts extensive antiviral function via selective stimulation of interferon λ1 (IFN-λ1)
P921
Q50259613-016511D6-D993-49B7-B007-B457BFA6E535Q50260873-897E47DE-B5DA-4766-BB61-85A6010E9444Q50260876-EA7B5CF8-7BD9-4E39-8EB3-6A2E332BC0A2Q50260882-E0A7740F-18C6-4D0A-AFCD-A952CA3E2597Q50260886-5D1DBF77-3387-40A2-ACD6-65D22E5C2490Q50261556-0DF32A1A-7F97-4386-AAE2-1AC8098C7ED3Q50261603-B77FA2E6-CC71-4AB0-BA61-FB1927513D4CQ50261606-16C99F90-CB15-4CB6-8B81-977302560451Q50261636-A471DC94-3699-4F86-9C14-5FF0A958671DQ50261664-E4CA9EF9-6992-4635-A6FF-4D51894B2628Q50261679-CF00AE1B-2F12-48F4-BD74-8B15084AAE94Q50261723-F8EE2EAD-6ABA-4F4E-A0AC-F82015BE4746Q50262518-70233E8F-ABCA-4DEE-8491-FF277DF89D17Q50292063-DC7F2926-A190-4AD0-AEE8-D586457031D7Q50292082-754FFBDD-D603-46EE-88DE-EDAFF0658091Q50292477-EC49A066-97A0-4D7A-8C80-DF483D263561
P527
Q24293312-1F3C4B68-3808-46B6-A6AA-CB88A8FA1D51Q24293755-07D5094B-7E47-48D0-927A-3E061D630F18Q24296473-20115519-64F3-4E8C-B1EE-642CDA623766Q24297421-DC9A131D-D4A3-4639-883A-EC649A2A040DQ24299651-4483069C-46AC-425E-8894-6AB15AF165AAQ24300398-BE30FA36-54EE-4614-B1CA-D9BC614B6370Q24303448-F6B38D8A-F4F7-452D-82B4-90BB0376EF76Q24307162-DC593BFE-0C0B-4409-A933-11F922DD7A41Q24307928-2D3D6286-5AEA-4038-92CB-879DA7D7584DQ24311045-F7B87088-D91B-48E9-876E-9FB7F9D9BD95Q24311228-7BB7D2A8-ECA2-4B1C-AF4C-CD6A38967F43Q24312113-44CCB334-D7F5-4FB8-BB57-295B0DB77C6FQ24316038-B38663D3-D8A3-42C4-BDF1-77883D171931Q24316320-22ABC340-E010-4889-AA6D-6C06BDD27F08Q24322120-932B89EB-F368-4E12-AA79-0DE1A393F726Q24336528-B4596C69-A331-4393-8222-3DB0693AAC54Q24633195-06760E73-C98F-47E1-9B7B-DD744FC37128Q27635163-CA57E79F-CD79-41FE-A614-5AD0B3005300Q27645541-CADF31FC-A63A-4C47-BEA9-A9C68094F057Q27651800-0971900D-F6B0-4BFC-86DC-104A68585A6AQ27678533-2AB75A48-4937-45E1-BA3C-0676E79D5C3BQ28256216-AAE33AF8-BA7C-4C02-803E-EE6AFE190085Q28609049-C55095DB-F053-422C-B99A-401A21B243A4Q34259150-5B2D158D-1C1B-4096-96D6-A4F1A0452039Q37175095-AF994583-65F4-41A9-8783-80FB0D95FEE8
P921
description
humanes Protein
@de
mammalian protein found in Homo sapiens
@en
menselijk eiwit
@nl
protein
@id
protein
@sv
proteinë
@sq
protèin
@ace
protéine humaine
@fr
بروتين بشري
@ar
name
IRF3
@ru
Interferon regulatory factor 3
@en
Interferon regulatory factor 3
@nl
type
label
IRF3
@ru
Interferon regulatory factor 3
@en
Interferon regulatory factor 3
@nl
altLabel
IRF3
@en
interferon regulatory factor 3
@en
uniprot:Q14653
@en
prefLabel
IRF3
@ru
Interferon regulatory factor 3
@en
Interferon regulatory factor 3
@nl
P361
P527
P637
P638
P680
P681
P682
P705
P352
P637
P31
P352
P361
P527
P637
NP_001184051
NP_001184052
NP_001184053
NP_001184054
NP_001184055
NP_001184056
NP_001184057
XP_006723260
XP_006723261
P638
P680
P682
P702
P703
P705
ENSP00000310127
ENSP00000366339
ENSP00000366344
ENSP00000400378
ENSP00000468911
ENSP00000469067
ENSP00000469113
ENSP00000470069
ENSP00000470140
ENSP00000470431