about
The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling.Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling.Circulating primers enhance platelet function and induce resistance to antiplatelet therapy.Insulin-like growth factor-II is produced by, signals to and is an important survival factor for the mature podocyte in man and mouse.NADPH oxidase NOX2 mediates rapid cellular oxidation following ATP stimulation of endotoxin-primed macrophages.A key role for redox signaling in rapid P2X7 receptor-induced IL-1 beta processing in human monocytes.Identification of roles for the SNARE-associated protein, SNAP29, in mouse platelets.Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets.Protein kinase C and P2Y12 take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets.Species and agonist dependent zinc modulation of endogenous and recombinant ATP-gated P2X7 receptors.Phosphoinositide 3-kinases p110α and p110β have differential roles in insulin-like growth factor-1-mediated Akt phosphorylation and platelet priming.Phosphoinositide 3-kinase p110α negatively regulates thrombopoietin-mediated platelet activation and thrombus formation.Aquaporin-1 regulates platelet procoagulant membrane dynamics and in vivo thrombosis.Phenotype description and response to thrombopoietin receptor agonist in -related disorderCritical roles for the phosphatidylinositide 3-kinase isoforms p110β and p110γ in thrombopoietin-mediated priming of platelet functionDysfunction of the PI3 kinase/Rap1/integrin α(IIb)β(3) pathway underlies ex vivo platelet hypoactivity in essential thrombocythemiaIn-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function
P50
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P50
description
researcher ORCID ID = 0000-0003-0944-7055
@en
wetenschapper
@nl
name
Samantha F Moore
@ast
Samantha F Moore
@en
Samantha F Moore
@nl
type
label
Samantha F Moore
@ast
Samantha F Moore
@en
Samantha F Moore
@nl
prefLabel
Samantha F Moore
@ast
Samantha F Moore
@en
Samantha F Moore
@nl
P31
P496
0000-0003-0944-7055